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Indirect modulation of cardiac ion channels and implications for preclinical safety assessment

19 August 2010 | By Gül Erdemli & Dmitri Mikhailov, Center for Proteomic Chemistry, Novartis Institutes for BioMedical Sciences and Albert M Kim, Translational Medicine, Novartis Institutes for BioMedical Sciences

The preclinical assessment of a small molecule’s liability for QT interval prolongation is an essential part of the drug discovery process. Patch clamp assays for heterologously expressed recombinant cardiac ion channels are widely used in the pharmaceutical industry to evaluate potential drug-channel interactions. These assays are generally acute assessments and…

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Outsource to Europe

2 July 2010 | By NG Online News

The pharmaceutical industry has faced well documented challenges over the last 12 months, such as the Pfizer...

news

Novartis data at ECFS

17 June 2010 | By CCA on behalf of Novartis

Data presented at the ECFS Conference in Valencia demonstrate that TIPTM* is as effective as the current standard of care...

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Maximising the efficiency and application of automated planar patch clamp electrophysiology

21 September 2007 | By Paul J Groot-Kormelink PhD, Pamela R Tranter PhD and Martin Gosling PhD, Novartis

The widespread expression of ion channels and their ability to significantly modulate cell function makes them attractive drug targets1. Therapeutic agents which target ion channel proteins comprise the third best selling class of prescription drugs with US sales in 2002 estimated at $12 billion. Somewhat surprisingly the discovery of many…