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Anti-Cancer Therapeutics

UMC Utrecht’s new liver cancer treatment approved for use in Europe

14 April 2015 | By Victoria White

A new liver cancer treatment developed by the UMC Utrecht that uses uses radioactive holmium microspheres has received the European CE mark...

news

Inovio’s INO-3112 DNA immunotherapy shows positive preliminary results

9 April 2015 | By Victoria White

INO-3112 DNA immunotherapy has generated strong T cell responses in patients with head and neck cancer associated with human papillomavirus (HPV)...

news

Exelixis’ cabozantinib granted Fast Track designation by FDA for advanced renal cell carcinoma

9 April 2015 | By Victoria White

Exelixis has announced that the FDA has granted Fast Track designation to cabozantinib for treatment of patients with advanced renal cell carcinoma...

news

Advaxis and Merck announce initiation of enrollment in the Phase 1/2 study of ADXS-PSA in combination with KEYTRUDA®

8 April 2015 | By Victoria White

Advaxis and Merck have initiated enrollment in the Phase 1/2 clinical trial evaluating the combination of ADXS-PSA and KEYTRUDA in patients with mCRPC...

news

Lion Biotechnologies announces publication of data from clinical study of metastatic cervical cancer patients treated with HPV-TIL

8 April 2015 | By Victoria White

Lion Biotechnologies has announced that data from a study of metastatic cervical cancer patients treated with treated with HPV-TIL has been published...

news

Apceth initiates Phase II clinical trial for pioneering engineered cell therapy to treat gastrointestinal cancer

26 March 2015 | By Victoria White

Apceth has announced the successful completion of the Phase I and initiation of the Phase II with the engineered cell therapy product Agenmestencel-T...

article

TandAbs: potent and well-manufacturable bi-specific antibodies for immunooncology

10 March 2015 | By Michael Weichel, Kristina Ellwanger, Ivica Fucek, Stefan H.J. Knackmuss, Erich Rajkovic, Uwe Reusch, Claudia Wall, and Eugene A. Zhukovsky, Affimed Therapeutics AG

The bi-specific antibody format is becoming the preferred antibody modality for current development projects in the pharmaceutical industry. This is due to an unsurpassed increase in functional activity relative to traditional mono-specific monoclonal antibodies, and a breakthrough in manufacturability enabled by novel designs. One such bi-specific format, the TandAb, produces…

news

Antibody Drug Conjugates (ADC)

19 February 2014 | By Paul Wituschek, Vice President of Sales, Development and Clinical Services, Catalent

Paul Wituschek, Vice President of Sales, Development and Clinical Services, Catalent answers the question: "Other than oncology, for which disease areas do you see Antibody Drug Conjugates (ADC) being used extensively in the future?"

article

Gene to drugs: can expression be the key to new discoveries?

25 February 2013 | By Esther P. Black, College of Pharmacy and Markey Cancer Center, University of Kentucky

Cancer treatment faces a conundrum: a growing lack of therapeutics with lasting effects. The low hanging fruit of the medicinal chemistry orchard seems to have been picked, and modification of existing anti-cancer therapeutics has produced only incremental rewards[1]. Thus, both pharmaceutical companies and academic researchers are left searching for new…

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Anti-Cancer Therapeutics