The efficacy, safety and pharmacokinetic properties of a protein therapeutic substantially depend on the molecule having the right structure. This article reviews current methods used for obtaining higher order structure information of biotherapeutics.
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Expert View: Eshmuno® CP-FT resin – developed for the flow-through removal of aggregates using frontal chromatography
28 June 2019 | By Merck
Eshmuno® CP-FT cation exchange resin is specifically designed to provide efficient removal of monoclonal antibody (mAb) aggregates in the flow-through frontal chromatography mode of operation enabling loading capacities 10-times higher than traditional bind/elute CEX chromatography. It facilitates greater manufacturing flexibility and process intensification while reducing the overall cost for the…
26 June 2019 | By PharmaFluidics
The practice of bottom-up proteomics relies to a large extent on the separation performance that can be achieved with state-of-the art nano LC-MS/MS equipment.
Scientific poster: Nuvia aPrime 4A: a hydrophobic anion exchange resin for refined selectivity and recovery
21 June 2019 | By Bio-Rad
The elimination of product and process related impurities is essential to the safety and efficacy of biopharmaceuticals.
5 June 2019 | By Sartorius
This whitepaper demonstrates the High Performance Liquid Chromatography (HPLC) separation and analysis technique and highlights the importance of using water of sufficient purity as an eluent and how the arium® pro VF system can facilitate this.
13 March 2019 | By BUCHI Laboratory Equipment
As maintaining the health of the chemist is of top priority, one should recognise potential dangers that can jeopardise the safety of laboratory staff and install measures to sufficiently protect the scientists.
12 March 2019 | By Nikki Withers (European Pharmaceutical Review)
A project backed by major pharma will advance the Lab of the Future with proof of concept software to digitise experiment methods…
PharmaFluidics’ new product launch steers ‘on-a-chip’ separations of complex biological samples to new heights
6 February 2019 | By PharmaFluidics
PharmaFluidics NV is a game-changing innovator in the field of analytical chromatography. The company has devised a fundamentally new way of performing separations by creating nano-LC columns on a silicon chip...
2 November 2018 | By Ioannis A. Papayannopoulos (Celldex Therapeutics Inc.)
For several decades mass spectrometry (MS) has been used in the characterisation of protein pharmaceuticals.1-3 However, its use in the laboratory for quality control (QC) product release testing has been quite limited for a number of reasons, for example: instrument complexity and software are not readily amenable to validation, extensive…
Scientific Poster: Quantitation of monoclonal antibody infliximab in human plasma by LC-MS/MS using Fab-selective limited proteolysis nSMOL technology
6 September 2018 | By Shimadzu
Infliximab, commercially known as Remicade, is a chimeric IgG1 kappa monoclonal antibody (mAb), that targets tumor necrosis factor-alpha (TNF)....
21 June 2018 | By Thermo Fisher Scientific
Multi-step, automated workflows designed to be versatile, fast and offer high throughput...
18 June 2018 | By Waters
New state-of-the-art facility will support continued growth and innovation...
14 June 2018 | By Thermo Fisher Scientific
Easy-to-use software helps identify unknown compounds and extracts high-confidence understanding from complex mass spectra...