Fit-for-purpose miniature NIR spectroscopy for solid dosage manufacturing
Near infrared spectrometers have long been the PAT tools of choice for pharmaceutical and industrial scientists seeking to gain physical and chemical information from their samples. More recently, the development of fast and inexpensive miniature NIR instruments has greatly facilitated real-time in-line monitoring of multiple unit operations within a process. NIR can be used as a supervisory tool for multiple critical quality attributes of a drug product. Deviations from the acceptable ranges can be acted on in real-time based upon closed-loop control strategies.
This webinar discusses how miniaturised spectrometers facilitate testing of different control schemes with the goal of enabling real-time feedback control of continuous manufacturing processes.
Chris Pederson, Product Applications Engineer, Viavi
Chris has 15 years of experience in applications of Near Infrared, Raman and Infrared in Pharmaceutical, food and beverage, agriculture and mining industries. Chris holds Bachelor’s degrees in Chemistry and Biology from Northern State University in Aberdeen SD and a MBA from Regis University in Denver CO.
Chris will present the principle of operation of the linear variable filter-based miniature NIR spectrometers, i.e., the MicroNIR Spectrometers developed by Viavi Solutions. He will also share key performance attributes of these ultra-compact MicroNIR products, and their applications in the pharmaceutical industry.
Krizia M. Karry, Principal PAT Scientist within the Drug Product Center of Excellence, Bristol-Myers Squibb.
Krizia recently earned a PhD in Chemical and Biochemical Engineering from Rutgers University. Her dissertation focused on the development and optimization of flexible continuous manufacturing platforms for delivery of poorly-soluble drugs. Krizia has extensive experience in the pharmaceutical industry, having worked as a consultant in the area of PAT and chemometrics. She has presented at numerous conferences including the EAS, IFPAC, Excipient Fest and AAPS, and has won awards for her presentations and advanced multivariate models. Krizia has coauthored several book chapters and scientific articles on process engineering and control, implementation and validation of PAT tools for real-time process monitoring, and novel techniques for drug delivery.
Krizia will present results of the MicroNIR spectrometer and its application for testing various control schemes and enabling real time feedback control of a continuous manufacturing process for tablets.
Supported by Viavi Solutions Inc.
Viavi helps ensure top performance in virtually every major network—from the NOC to field technicians—and over 100,000 data centers worldwide, from deployment and installation to monitoring and optimisation. For nearly 100 years, Viavi has innovated solutions to optimise communications technologies, from simple radio test sets to sophisticated network assurance platforms. Always an industry leader, the company has consistently complemented its strong R&D roots with smart, strategic acquisitions and mergers.
Find out more: www.viavisolutions.com