This article describes headspace gas ingress as a CCI test method, which is increasingly being implemented to replace blue dye.
Laser-based headspace analysis is a deterministic Container Closure Integrity test technique described in USP <1207> that measures gas which ingresses into a container through a leak defect. Headspace gas ingress methods are analytical and nondestructive and can be validated to detect critical leaks. This article describes the headspace gas ingress testing approach which is increasingly being implemented to replace blue dye ingress as a general CCI test method.
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