Whitepapers/App Notes/Posters

Application Note: Analysis of Compound Combination Experiments

Posted: 13 January 2015 |

With recent improvements in automation and liquid handling, compound combination experiments can be executed at higher throughput than ever before. However, software tools have not kept up with this increase and often still require either a manual, percombination workflow or cover just the synergy calculation without the necessary pre-processing steps. In this application note we describe how compound combination experiments should ideally be analysed.

The earliest work formulating a systematic methodology for assessing combination effects was done by Loewe and Fraser (1928, 1872). The principal assumption is that two compounds combined in one organism may have a different effect than the two compounds individually. The whole purpose of compound combination studies is to identify and quantify effects such as synergism and antagonism in the organisms under study.

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