Whitepaper: Understanding the links between drug delivery route and in vitro test methods
In this whitepaper, Copley Scientific review drug product characteristics that define the success of delivery via any given route, and the tests used to measure them…
In vitro tests are widely used, from R&D through to QC, to improve the efficacy of drug delivery and confirm product consistency. Ensuring a drug reaches its intended site of action in vivo, in an appropriate state, is a crucial first step towards meeting clinical performance goals.
Drugs may be delivered by the gastrointestinal tract; or via the rectal and vaginal mucosal membranes; through the surface of the skin; or by inhalation via the nose or lungs. In each case the requirements for effective delivery are different and the tests applied to assess drug performance differ accordingly.
In this introductory white paper we review the drug product characteristics that define the success of delivery via any given route, and the tests used to measure them. A key focus is the link between the mechanisms of drug delivery and the test conditions applied.
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