Cellular Pathways - Articles and news items

Figure 1 Cell undergoing senescence. Cell showing characteristics of cellular senescence: binucleated and flat and enlarged morphology

Cellular senescence as an anti-tumour mechanism

Cancer Biology, Issue 3 2010, Past issues / 24 June 2010 / Amancio Carnero, Scientist, Seville Biomedical Research Institute (IBIS/HUVR), Spanish National Research Council

One of the critical steps in human carcinogenesis is cellular immortalisation, a process in which cells must escape senescence and acquire an infinite lifespan. In the absence of immortalisation, although a cell might undergo malignant transformation, it could not proliferate indefinitely. Furthermore, it has been clearly established in vitro and in vivo that cellular senescence is a tumour suppressor mechanism induced by oncogenic stress. Normal somatic cells grown in culture cease to proliferate, senesce, after a finite number of divisions.

Genome-wide High Content Analysis of cellular pathways

Issue 1 2008, Past issues / 23 January 2008 /

Creating the molecular tools to combat human disease and infection remains the cornerstone activity of the pharmaceutical industry. The methodologies employed to discover new drugs has continually evolved as new biological techniques have emerged1; nevertheless the development of each novel compound is still only realised after many years of careful research, and a detailed analysis […]


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