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Dosage - Articles and news items

finished dosage

Experts analyse growth in the finished dosage market ahead of CPhI Worldwide launch

Industry news / 6 June 2016 / CPhI

The new Finished Dosage Formulation (FDF) event will be the first global pharma platform dedicated to the manufacture, development and supply of finished dosage forms…

Dennis Douroumis

Hot melt extrusion processing for the development of sustained release products

Ingredients, Issue 2 2014 / 15 April 2014 / Dennis Douroumis, Reader in Pharmaceutical Sciences at the University of Greenwich and the Director of Centre for Innovation in Process Engineering and Research

Hot Melt Extrusion (HME) has attracted increased interest for the development of pharmaceutical dosage forms over the last decade. It is a versatile processing technology which produces extrudates in the form of solid dispersions and solid solutions. Among the various applications, HME has been adopted for the development of sustained release dosage forms by using a wide range of pharmaceutical excipients such as polymers or lipids. In this review, we highlight the development and recent trends of sustained release dosages manufactured by extrusion processing.

Figure 2

Applications of Raman, CARS and SRS imaging in dosage form development

Issue 2 2012, Raman Spectroscopy / 26 April 2012 / Clare Strachan, Senior Lecturer Pharmaceutical Sciences, School of Pharmacy, University of Otago

The use of Raman spectroscopy in pharmaceuticals has grown enormously since its appearance on the scene in the 1980s1-4. While typical Raman spectroscopy setups are able to provide chemical and physicochemical information about the sample on the bulk level, most solid samples in the pharmaceutical setting may not be assumed to be homogenous, and many critical quality attributes, such as drug release for example, depend on component distribution. Thus, obtaining chemically and spatially resolved information about pharmaceutical samples is pertinent. Since Raman microscopy imaging made its debut in the pharmaceutical setting, the range of pharmaceutical applications for which the technique has been used has continued to grow5-7.

Briefly, Raman spectroscopy involves the detection of inelastic scattering of light associated with molecular vibrations. The resulting photons have a longer (Stokes scattering) or shorter wavelength (anti-Stokes scattering) than the incident photons. In the most common setup (with spontaneous Raman scattering), the Stokes effect is detected since it is stronger. Raman spectroscopy is related to (near- and mid-) infrared spectroscopy since both techniques probe molecular vibrations, but there are several practical differences, which are due to the different molecular phenomena behind Raman scattering (polarisability change during vibration) and infrared absorption (dipole moment change, for more detail see e.g.8,9,5 for a brief explanation). While near-infrared and mid-infrared micro – scopy may also be used to gain chemically and spatially resolved information about samples, Raman microscopy has some advantages which include:

Figure 1 Examples of chemical structures of antibodies for targeted pulmonary inhalation aerosol

Pulmonary inhalation aerosols for targeted antibiotics drug delivery

Ingredients, Issue 1 2011 / 16 February 2011 / Chun-Woong Park & Heidi M. Mansour, University of Kentucky, College of Pharmacy and Don Hayes Jr, University of Kentucky, College of Medicine

Targeted pulmonary drug delivery of antibiotics by inhalation aerosols can play significant roles in the treatment of cystic fibrosis (CF), chronic obstructive pulmonary disease (COPD) and in other pulmonary diseases where chronic airway infections exist. Direct administration to the lung as targeted pulmonary inhalation aerosol delivery is uniquely able to provide for high dose levels of drugs at the target site of action without systemic side effects. This review presents an overview of pulmonary inhalation aerosols, types of inhalation aerosols, aerosol formulation additives and present current research in the targeted pulmonary drug delivery of antibiotics for the treatment of pulmonary infections. Clinical trials of antibiotic inhalation aerosols are also discussed.


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