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Comparative evaluation of pharmaceutical powder flow using different analytical methodologies

Glidants and lubricants are important additives in the production of solid dosage formulations. This article compares the results of various methods to characterise the flowability of blends, demonstrating the importance of considering the impacts that glidants may have, not only on the flowability of blends, but the physical attributes of the final tablet.

Introduction

In solid dosage formulations, glidants are added to the blends with the intention of improving their flow. Methods to characterise the flowability of blends are numerous and include conventional angle of repose, critical orifice and other more innovative methods of characterisation using powder rheometers.1,2 Powder rheometers have the advantage of being able to evaluate the bulk, shear and dynamic flow properties of blends.3 The primary goal of this work was to carry out a systematic evaluation of flow improvement by different flow additives using different analytical methodologies, and then compare the flowability results collected from the different tests with final tablet attributes.











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