DNA microarrays and multidrug resistant bacteria
In parallel with the use of a wide range of antibiotics for treating infectious diseases worldwide, antimicrobial resistance has significantly increased. For this reason, the application of an advanced pangenomic technique like DNA microarray can be an effective, rapid, accurate, sensitive, specific and flexible methodology for detecting, identifying and determining antimicrobial-resistant bacteria.
In the ancient world, including Ancient Persia (Iran – in particular, near the Caspian Sea in the North and the Persian Gulf in the South of Iran’s plateau), plants, medicinal herbs and fungi were used to treat various diseases and infections. Today, in addition to medicinal herbs, plants and fungi, different types of antibiotics taken from bacteria and fungi are used as the main option for medical treatment. Simultaneously, with the beginning of the use of medicinal substances and antibiotics, resistant strains of microorganisms began to emerge.1,2
Antibiotic-resistant bacteria are not a new feature in medicine, but increased antibiotic use leading to multi-drug resistance is now a global healthcare concern. Methicillin-resistant Staphylococcus aureus (MRSA), methicillin-resistant it Staphylococcus epidermidis (MRSE), vancomycin-resistant Enterococci (VRE), and pandrug-resistant bacteria such as Acinetobacter baumannii, Escherichia coli and Pseudomonas aeruginosa, are important common multidrug-resistant bacteria that can cause complicated morbidity and even mortality.3-6