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Ioannis A. Papayannopoulos (Celldex Therapeutics Inc.)

 

LC-MS based multi-attribute method for characterisation and QC testing of protein therapeutics

2 November 2018 | By

For several decades mass spectrometry (MS) has been used in the characterisation of protein pharmaceuticals.1-3 However, its use in the laboratory for quality control (QC) product release testing has been quite limited for a number of reasons, for example: instrument complexity and software are not readily amenable to validation, extensive…

Characterising therapeutic antibodies and ADCs using mass spectrometry

24 August 2016 | By

Since the 1970s, the advent of biotechnology has resulted in the development and commercialisation of many therapeutic proteins, including antibodies and antibody fragments, for the treatment of human diseases. Examples include antibody treatments for autoimmune diseases (for example, adalimumab [Humira┬«] for rheumatoid arthritis), cancers (such as trastuzumab [Herceptin┬«] for breast…