Early response to Saxenda results in improvement in weight loss
Posted: 3 June 2016 | | No comments yet
Three-year data show early response to Novo Nordisk’s Saxenda (liraglutide 3 mg) resulted in improvements in weight loss and cardiometabolic risk factors…
Three-year data presented at the European Obesity Summit (EOS 2016) show early response to Novo Nordisk’s Saxenda (liraglutide 3 mg) resulted in improvements in weight loss and cardiometabolic risk factors.
In the Phase IIIa SCALE trial, adults with prediabetes and obesity or who were overweight with comorbidities were randomised to receive Saxenda or placebo for 160 weeks, both as an adjunct to a reduced-calorie diet and increased physical activity. People treated with Saxenda who lost 5% or more of their body weight at 16 weeks (classified as ‘early responders’) demonstrated greater weight loss and improvements in cardiometabolic risk factors at week 160 compared with those who lost less than 5% of their body weight at 16 weeks (‘early non-responders’).
At week 16, 68.0% of people treated with Saxenda were early responders versus 22.3% of people treated with placebo. At week 160, Saxenda early responders who completed the trial achieved an average weight loss of 8.6% (9.1 kg), compared with 2.9% (3.1 kg) in early non-responders.In addition, Saxenda early responders experienced improvements across a range of glycaemic measures including regression to normoglycaemia (69.8 vs 55.4%) and reduced development of type 2 diabetes (0.5 vs 3.2%) compared with early non-responders.
Commenting on the data, Professor Sten Madsbad, Clinical Professor at the University of Copenhagen and SCALE clinical trial investigator, said: “These findings demonstrate the predictive nature of an early response to treatment, which is important information that clinicians can use to identify those who are most likely to experience long-term benefits with Saxenda. It is also encouraging that we continue to see benefits in addition to weight loss experienced with Saxenda, including improvements in cardiometabolic risk factors and glycaemic status for people completing the trial.”
Improvements in QoL
For those completing 160 weeks of treatment, Saxenda early responders also experienced greater improvements in systolic blood pressure (-3.7 vs -3.3 mmHg), and improvements in health-related quality of life measures (IWQoL-Lite score 13.4 vs 9.5) compared with early non-responders.
Saxenda was generally well-tolerated, and observed side effects were in line with previous trials. Rates of adverse events were similar between early responders and early non-responders (97.1 vs 95.0%). The most common side effects reported by early responders and early non-responders were related to the gastrointestinal system (75.3 vs 71.6%). Gallbladder disorders were more frequent in early responders compared with early non-responders (6.3 vs 2.2%).