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Protein-protein interactions (PPI)

 

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Cell-based assays for protein-protein interactions

22 October 2013 | By Mark Wade, Center for Genomic Science of [email protected]

Protein-protein interactions (PPI) form the backbone of all cellular signalling networks, and aberrant PPI contribute to the pathology of several diseases. Thus, strategies to identify PPI modulators are expected to be therapeutically beneficial. However, there are very few examples of clinically approved PPI modulators, reflecting the difficulties of identifying effective…