Application note: Disintegration property of ODTs with co-processed excipients

Performance of orally disintegrating tablets (ODTs) with GRANFILLER-D was investigated by the real-time X-ray observation of water penetration into ODTs.

Orally disintegrating tablets (ODTs) have gotten attention as they improve medication adherence for patients who have issues in swallowing, such as geriatric and pediatric patients. Co-processed excipients are available as a time-saving tool for manufacturers to formulate ODTs as they consist of several excipients. In this study, the performance of the co-processed excipient GRANFILLER-D was investigated by the real-time observation of water penetration into ODTs utilizing a synchrotron radiation X-ray.

Authors Bio

Yukiko Suganuma:

Yukiko Suganuma is in charge of technical support and marketing in Daicel Corporation in Japan. She earned her PhD in Physics at Ochanomizu University working in the field of soft matter. After a career in R&D for personal care products, she joined Pharma Solutions, Daicel Corporation in 2018.

Dr. Helene Wall:

Helene Wall is a Technical Sales Manager at HARKE Pharma GmbH. She received her PhD in organometallic Chemistry at the Technical University of Dortmund working in the field of (Aminomethyl)ferrocenes. After a career at the University she joined HARKE Pharma GmbH in 2019.