Whitepaper/App Note

Application Note: Are you seeing the whole picture with Raman?

Posted: 15 January 2016 | | No comments yet

Raman spectroscopy offers a rapid, convenient method for positive identification of pharmaceutical products and their raw materials – on the manufacturing floor, in inventory, and at the shipping dock.

Not only is this spectral fingerprinting method non-contact, but it can also penetrate glass and plastic packaging. This eliminates the need to open blister packs, pill bottles or vials, and simplifies the process of identification. Many commercial Raman instruments, however, sample a very small area of the product, and thus may provide an incomplete picture of overall composition when it comes to pharmaceuticals.

Pharmaceuticals that combine multiple APIs with excipients like fillers, binders, colouring agents, preservatives and/or sweeteners tend to be inhomogeneous when viewed at a microscopic scale. Depending on the interrogation area of the Raman probe relative to the crystal size and degree of inhomogeneity within the product under test, a static Raman probe may not see all components within the sample equally with a single measurement.

This application note is restricted - login or subscribe free to access

epr 3 2018 magazine coverThank you for visiting our website. To access this content in full you'll need to login. It's completely free to subscribe, and in less than a minute you can continue reading. If you've already subscribed, great - just login.

Why subscribe? Join our growing community of thousands of industry professionals and gain access to:

  • bi-monthly issues in print and/or digital format
  • case studies, whitepapers, webinars and industry-leading content
  • breaking news and features
  • our extensive online archive of thousands of articles and years of past issues
  • ...And it's all free!

Click here to Subscribe today Login here

 

Related topics

Related organisations

Send this to a friend