There has been a lot of interest in enhancing the sensitivity of Raman spectroscopy due to the low efficiency of the Raman technique. A pre-concentration technique, drop-coating deposition Raman (DCDR), has been used in recent years to increase the utility of Raman spectroscopy by decreasing the detection limit for non-enhanced…
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Recent developments of Raman spectroscopy for the qualitative analysis of falsified and substandard medicines
2 January 2019 | By Charlotte De Bleye (University of Liege Belgium), Elodie Dumont (University of Liege Belgium), Eric Ziemons (University of Liege Belgium), Hermane Avohou (University of Liege Belgium), Laureen Coic (University of Liege Belgium), Philippe Hubert (University of Liege Belgium), Pierre-Yves Sacre (University of Liege Belgium), Riccardo Deidda (University of Liege Belgium), Roland Marini (University of Liege Belgium)
Quality medicines are essential to any healthcare system and are the final goal of any pharmaceutical manufacturer. Unfortunately, as stated recently by the World Health Organization (WHO), one in 10 medical products circulating in low and middle-income countries is either substandard or falsified (SF products).1 Although the exact prevalence of…
Expert View: Beyond API monitoring: in‑line Raman spectroscopy for bioprocess monitoring and control
19 December 2018 | By Kaiser Optical Systems
The FDA’s Quality by Design (QbD) initiative brought a paradigm shift to pharmaceutical manufacturing and leading manufacturers have realised improved processes after adopting QbD. Raman spectroscopy is an established Process Analytical Technology (PAT), enabling QbD and continuous approaches to pharmaceutical manufacturing.1
19 December 2018 | By Harald Fischer
Sophisticated hardware and software offer speed and precision. Pharmaceutical development often involves samples in solution or on transparent substrates. For these applications, confocal Raman imaging using an inverted beam path is an especially versatile and powerful investigative method.
17 December 2018 | By European Pharmaceutical Review
In this issue: Navigating roadblocks to clinical success: decision-making from molecule to clinic, Raman spectroscopy for the qualitative analysis of falsified and substandard medicines, and an overview of risk assessments for elemental impurities: implementation of ICH Q3D guidelines.
13 December 2018 | By WItec GmbH
90 years ago Chandrasekhara Venkata Raman and Kariamanickam Srinivasa Krishnan first documented "A New Type of Secondary Radiation," which then became known as the Raman Effect [1, 2]. Raman spectroscopy is based on this effect and is used for qualitative and quantitative analysis of the chemical components and molecules of…
12 December 2018 | By Thermo Fisher Scientific
The rapid increase in demand for biopharmaceuticals presents manufacturers with unique challenges to ensure quality and regulatory compliance while maintaining supply and production capacity.
12 December 2018 | By Kaiser Optical Systems
Raman spectroscopy is an analysis technique that provides a “molecular fingerprint” of the sample, enabling analysis of chemical composition and molecular structure without sample preparation. As a measurement technique, Raman imparts many benefits in applications from laboratory discoveries to feedback-control in manufacturing.
28 November 2018 | By Thermo Fisher Scientific
TruScan RM with TruTools extends raw material identification to complex analysis problems such as quantification of components and final product identification.
27 November 2018 | By BrightSpec
BrightSpec is first to commercialise molecular rotational resonance (MRR) spectroscopy for drug discovery and process R&D applications.
27 July 2018 | By Mike Stones
Raman spectroscopy can help to detect post-traumatic stress disorder syndrome by revealing the levels of stress hormone in human hair.