Whitepaper: Accelerating development of enabled formulations for poorly soluble drugs
In this whitepaper, Quotient Clinical discuss poorly soluble drugs and how they have developed an innovative approach to identify and overcome these solubility challenges…
Efficacy issues due to inadequate gastrointestinal (GI) absorption caused by insufficient aqueous solubility are encountered in up to 70% of new drugs in development. Typically, in vitro analysis and preclinical studies are used to predict the behaviour of the drug in vivo.
These methods are notoriously poor at predicting drug behaviour in humans however, meaning that solubility issues are often only discovered when the drug is first administered in clinical trials. The drug substance and/or formulation must then be reworked and the process started again. The cost and time expended in this process can be considerable. Importantly, the selection of formulation prototypes to overcome a solubility issue using these tools also carries a significant risk of non-resolution in subsequent clinical testing.
This whitepaper is restricted - login or subscribe free to access
Thank you for visiting our website. To access this content in full you'll need to login. It's completely free to subscribe, and in less than a minute you can continue reading. If you've already subscribed, great - just login.
Why subscribe? Join our growing community of thousands of industry professionals and gain access to:
- bi-monthly issues in print and/or digital format
- case studies, whitepapers, webinars and industry-leading content
- breaking news and features
- our extensive online archive of thousands of articles and years of past issues
- ...And it's all free!
Related content from this organisation
- Quotient Clinical appoints Azhar Kalim as Chief Commercial Officer
- Whitepaper: Accelerating development of enabled formulations for poorly soluble drugs
- Spray drying – various challenges, one solution?
- Quotient Clinical hosts formulation development and drug delivery seminar series
- Quotient Clinical and Upperton announce a spray drying partnership to deliver integrated formulation development and GMP manufacturing programs for poorly soluble drugs