There are several problems with existing primary containers; for example, glass suffers from breakage, delamination, etc., and plastic is an insufficient oxygen and ultraviolet (UV) barrier.
These issues, especially with glass, have been highlighted by the US Food and Drug Administration (FDA), who suggest they have caused more than 50 recalls. To address this, many suppliers have launched alternative plastic vials and syringes, but the oxygen barrier has, so far, not met the customers’ demands.
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