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Andreas Abend (MSD)



Application of liquid chromatography in characterisation of lipid nanoparticle-based oligonucleotides

28 April 2020 | By , , ,

Duplex oligonucleotides (OGN) with lipid nanoparticles (LNPs) as delivery vehicles for different therapeutic indications are of great interest in pharma, exemplified by the recent approval of Onpattro from Alnylam Pharmaceuticals. Liquid chromatography is an essential analytical technique in the characterisation of LNPs containing OGNs. This brief review is intended to…