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Intravenous delivery of TB vaccine found to dramatically improve potency in models
New research has shown that intravenous injection of the BCG vaccine dramatically reduces monkey susceptibility to TB bacteria and lung inflammation.
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Exploring Raman: a non‐invasive analytical approach
Since it was discovered in the 1920s, Raman spectroscopy has been used in pharmaceutical research as a non‐invasive way to provide chemical and structural information in situ, without any staining or complicated sample preparation. Nikki Withers spoke to Professor Kishan Dholakia to hear more about its use in industry and…
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Leaked document reveals ‘unprecedented’ medicine shortages in NHS
A document from the DHSC has reportedly advised NHS doctors to ration certain medicines after outlining dozens of drugs that are in shortage, as published in a report.
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Thermally-stable TB vaccine developed using new technique
A new process developed by the University of Bath protects a TB antigen and a novel vaccine adjuvant from heat damage.
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Tuberculosis: fighting the disease with a single vial
Vaccinations have begun in a phase I human clinical trial testing a freeze-dried, temperature-stable formulation of an experimental tuberculosis vaccine candidate. Nikki Withers speaks to Dr Daniel Hoft and Christopher Fox about the formulation process and what this means for vaccine development going forward.
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Collaboration to produce new clinical stage TB drug candidates
The National Institute of Allergy and Infectious Diseases (NIAID) has awarded TB Alliance a CETR grant for tuberculosis drug development.
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Freeze-dried TB vaccine candidate enters Phase 1 human clinical trial
A vaccine that does not require a cold chain could be much more easily distributed to communities in need…
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Higher rifampin doses for TB appear more effective with no greater risks
Higher daily doses of rifampin, a cornerstone of tuberculosis treatment, were shown to kill more TB bacteria in sputum cultures without increasing the adverse effects of treatment, according to a recent randomised controlled trial.
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Repurposing cancer drugs may lead to a new approach to treating TB
Promising experimental cancer chemotherapy drugs may help knock out another life-threatening disease: tuberculosis (TB)...
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Cancer drug helps treat tuberculosis by restoring leaky blood vessels
Drug that strengthens blood vessels allows antibiotics to infiltrate tuberculosis granulomas in mice...
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Blood test found to predict onset of TB up to two years in advance
A new blood test has been found to more accurately predict the development of tuberculosis up to two years before its onset in people living with someone with active TB...
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Algorithm proves its worth in preventing spread of infectious diseases
Scientists in California have undertaken studies that have demonstrated the effectiveness of a sophisticated algorithm in preventing the spread of infectious diseases. The application of AI allows authorities to identify the best use of resources and highlight subtle interaction points that might otherwise be missed.
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TB vaccine trial results offer potential for BCG revaccination
Study is the first 'prevention of infection' trial conducted for tuberculosis, the world's leading infectious disease killer...
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New research into old antibiotic unearths potential improved TB drug
A study by the University of Warwick and the Francis Crick Institute has enabled a deeper understanding of the mechanism of action of antibiotic drug, D-cycloserine, which holds promise for future TB treatment.
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Lansoprazole a gastric acid suppressant may target TB
A cheap and widely used drug, used to treat conditions such as heartburn, gastritis and ulcers, could work against the bacteria that cause TB...