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One of the oldest vaccines could help combat COVID-19
Researchers have shown that recipients of the Bacillus Calmette-Guérin (BCG) vaccine are less likely to contract COVID-19 in a new study.
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The many advantages of repurposing existing drugs
Repurposing existing drugs can be attractive as the process is often less risky, more cost effective and can be undertaken in less time. This article discusses the logic behind drug repurposing and the approaches that are currently being explored.
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Patient adherence: the true costs
Adherence to medicines – ie, maintaining consistency and complying with correct dosage – is vital for treatment success, yet patient non-adherence remains a global concern, risking a multitude of consequences for both the patients and healthcare systems. Dave Elder explores the issue of medicine adherence and expounds on current efforts…
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Committee for Medicinal Products for Human Use (CHMP) meeting highlights
A summary of the CHMP meeting conclusions, including medicines recommended for approval and indication extension and several safety review findings.
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Global collaboration formed to develop novel treatment regimens for TB
The Project to Accelerate New Treatments for Tuberculosis (PAN-TB collaboration) was devised to create transformative regimens for TB treatment, irrespective of drug resistance status.
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Intravenous delivery of TB vaccine found to dramatically improve potency in models
New research has shown that intravenous injection of the BCG vaccine dramatically reduces monkey susceptibility to TB bacteria and lung inflammation.
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Exploring Raman: a non‐invasive analytical approach
Since it was discovered in the 1920s, Raman spectroscopy has been used in pharmaceutical research as a non‐invasive way to provide chemical and structural information in situ, without any staining or complicated sample preparation. Nikki Withers spoke to Professor Kishan Dholakia to hear more about its use in industry and…
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Leaked document reveals ‘unprecedented’ medicine shortages in NHS
A document from the DHSC has reportedly advised NHS doctors to ration certain medicines after outlining dozens of drugs that are in shortage, as published in a report.
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Thermally-stable TB vaccine developed using new technique
A new process developed by the University of Bath protects a TB antigen and a novel vaccine adjuvant from heat damage.
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Tuberculosis: fighting the disease with a single vial
Vaccinations have begun in a phase I human clinical trial testing a freeze-dried, temperature-stable formulation of an experimental tuberculosis vaccine candidate. Nikki Withers speaks to Dr Daniel Hoft and Christopher Fox about the formulation process and what this means for vaccine development going forward.
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Collaboration to produce new clinical stage TB drug candidates
The National Institute of Allergy and Infectious Diseases (NIAID) has awarded TB Alliance a CETR grant for tuberculosis drug development.
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Freeze-dried TB vaccine candidate enters Phase 1 human clinical trial
A vaccine that does not require a cold chain could be much more easily distributed to communities in need…
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Higher rifampin doses for TB appear more effective with no greater risks
Higher daily doses of rifampin, a cornerstone of tuberculosis treatment, were shown to kill more TB bacteria in sputum cultures without increasing the adverse effects of treatment, according to a recent randomised controlled trial.
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Repurposing cancer drugs may lead to a new approach to treating TB
Promising experimental cancer chemotherapy drugs may help knock out another life-threatening disease: tuberculosis (TB)...
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Cancer drug helps treat tuberculosis by restoring leaky blood vessels
Drug that strengthens blood vessels allows antibiotics to infiltrate tuberculosis granulomas in mice...