Biochemical Assay Development Using Novel MALDI High-Throughput Screening System
This whitepaper focuses on developing biochemical assays where substrate and product are small molecules using a novel MALDI-HTS system…
Label-free detection methods based on mass spectrometry are gaining momentum in high-throughput screening (HTS) for pharmaceutical drug discovery.
Most of these mass spectrometry methods are centred on multiplexed LC-MS and SPE-MS. MALDI-TOF has an inherent advantage over multiplexed LC-MS and SPE-MS techniques by being 10-100 times faster. MALDI-TOF methods can also significantly reduce costs, the amount of solvent being used and the amount of chemical waste being generated.
This work focuses on developing biochemical assays where substrate and product are small molecules using a novel MALDI-HTS system.