Whitepaper: Predicting the release of active ingredients from sustained-release tablets
Near-infrared spectroscopy, used in combination with an appropriate calibration model, offers an alternative to dissolution testing, making it possible to predict the dissolution of tablets accurately and within a matter of minutes…
After taking a tablet, a phenomenon known as a plasma peak usually occurs: this is when the full amount of the drug is rapidly released from the tablet and the active ingredient concentration temporarily reaches a high level in the patient’s blood plasma as a result.
Depending on the type of drug, this high concentration can cause significant side-effects. In addition, a high administration frequency is required to produce a lasting effect, as the high plasma level that patients experience at the outset then falls rapidly again as the active ingredient is metabolized.
Sustained release reduces side-effects
Sustained-release formulations, which release active ingredients gradually, offer a solution to these issues. The occurrence of a plasma peak is prevented and a reasonable plasma level is maintained over a longer period. In particular, hormone preparations, drugs for regulating blood pressure, painkillers, and antidepressants are often administered in the form of sustained- release tablets.
This whitepaper is restricted - login or subscribe free to access
Thank you for visiting our website. To access this content in full you'll need to login. It's completely free to subscribe, and in less than a minute you can continue reading. If you've already subscribed, great - just login.
Why subscribe? Join our growing community of thousands of industry professionals and gain access to:
- bi-monthly issues in print and/or digital format
- case studies, whitepapers, webinars and industry-leading content
- breaking news and features
- our extensive online archive of thousands of articles and years of past issues
- ...And it's all free!
Related content from this organisation
- Metrohm USA contributes to global monograph modernisation initiative
- New Metrohm Mira P for raw material verification
- Metrohm acquires innovative Photonic Solutions to expand Handheld Raman portfolio
- Application Notes & Whitepapers 2017
- Whitepaper: Do you know what’s going in? Analysing tablets by NIR spectroscopy