Scientific Poster: Development of cGMP-Ready purification process for advenovirus purification
Large-scale downstream processing of viruses for clinical applications poses challenges different from those for many other biotherapeutics…
These challenges mostly arise from the size and complexity of the virus. Here we present purification results of a cGMP-ready process developed for a recombinant adenovirus. The two-step column process results in an adenovirus preparation with high yield and very low host cell protein (HCP) and DNA contamination, comparable to clinical grade products. This process is readily scalable, simple, rapid, and efficient and is thus well-suited for the production of clinical grade viral vectors.
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Analytical techniques, Biopharmaceuticals, Bioprocessing, DNA, Downstream, Lab Automation, Lab Equipment, Manufacturing, Microbial Biological Manufacturing, Microbial Detection, Microbiology, QA/QC, Rapid Microbiological Methods (RMMs), Research & Development (R&D), RNA