Whitepaper: Logistic regression model of the endotoxin standard curve and statistical tests
The Monocyte Activation Test (MAT) is used to detect or quantify pyrogenic substances that activate human monocytes.
Pyrogenic substances in pharmaceutical products can induce life-threatening fever reactions after injection into the human body. Therefore, it is a regulatory requirement to test such products for pyrogens to ensure product quality and patient safety.
The MAT has been described as a compendial method for pyrogen detection in the European Pharmacopeia since 2010 (Chapter 2.6.30). It is a test that mimics the human reaction to pyrogens, by using a source of monocytes, which release some interleukins upon activation by pyrogenic substances:
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