Whitepapers/App Notes/Posters

Whitepaper: Logistic regression model of the endotoxin standard curve and statistical tests

Posted: 19 December 2018 | | No comments yet

The Monocyte Activation Test (MAT) is used to detect or quantify pyrogenic substances that activate human monocytes.

Pyrogenic substances in pharmaceutical products can induce life-threatening fever reactions after injection into the human body. Therefore, it is a regulatory requirement to test such products for pyrogens to ensure product quality and patient safety.

The MAT has been described as a compendial method for pyrogen detection in the European Pharmacopeia since 2010 (Chapter 2.6.30). It is a test that mimics the human reaction to pyrogens, by using a source of monocytes, which release some interleukins upon activation by pyrogenic substances:


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