Application note: Cleaning validation from HPLC to TOC: three factors to consider
Posted: 25 April 2019 | SUEZ | No comments yet
This application note from SUEZ outlines the factors that companies should consider when choosing their cleaning validation procedure, highlighting the benefits of TOC analysis over HPLC.
Total Organic Carbon (TOC) analysis is often preferred over traditional, product-specific methods for cleaning validation due to its speed, simplicity, and ability to enhance process understanding.
HPLC vs. TOC
TOC analysis offers several benefits over HPLC, including:
• Better process understanding
• Faster sample analysis
• Simpler method development
• Greater productivity
• Opportunity for at-line and online efficiency gains
• Lower operating costs.
Related content from this organisation
- TOC fitness for purpose: How to ensure your TOC analyser is fit for compendial water & cleaning validation
- Application note: Calculating maximum allowable carryover (MAC) for cleaning validation
- Application note: Cleaning validation from HPLC to TOC: three factors to consider
- Don’t let difficult substances control your cleaning validation
- Application note: Conductivity bridge study – from benchtop metre and probe to automated Sievers M9
Related topics
Drug Manufacturing, Drug Safety, HPLC, Manufacturing, Production, Total Organic Carbon (TOC)
