Application note: Rapid Analysis of Genotoxic Nitrosamines by HPLC-MS/MS
16 July 2019 | By Sciex
Genotoxic impurities (GTI’s) are intermediate, reactive products or degradants formed during drug synthesis, formulation or storage.
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HPLC
Whitepaper: Impact of the Claristep® Filtration System on recovery and adsorption of various therapeutic proteins at low sample volumes
10 July 2019 | By Sartorius
Comparison of the Sartorius Claristep Filtration System with standard sample preparation using syringe filters.
Analytical methods used in obtaining higher order structure information from protein therapeutics
1 July 2019 | By Ioannis A. Papayannopoulos, Shannon Renn-Bingham
The efficacy, safety and pharmacokinetic properties of a protein therapeutic substantially depend on the molecule having the right structure. This article reviews current methods used for obtaining higher order structure information of biotherapeutics.
Whitepaper: Supelco preparative HPLC products for pharmaceutical development and production
27 June 2019 | By Merck
There is an increasing need for purified materials in the development and production of pharmaceutical products. FDA and other regulatory agencies continue to require more stringent purity requirements on active pharmaceutical ingredients (API), including most recently chiral purity.
Article: Fast HPLC using fused-core particle technology for rapid screening of pharmaceutical compounds
25 June 2019 | By Merck
HPLC is critical to the discovery, development and eventual commercialization of pharmaceutical products. HPLC is the benchmark analytical method in the pharmaceutical industry due to its ability to score such high marks in analytical validation characteristics; including accuracy, precision, limit of detection, specificity, linearity and range, and ruggedness.
Article: Chiral method development strategies for HPLC
24 June 2019 | By Merck
Generic screening to provide fast solutions for chiral method development, whether needed for routine analytical use, trace analysis, LC/MS or preparative LC, has become increasingly important.
Whitepaper: Ultrapure water for HPLC analysis
5 June 2019 | By Sartorius
This whitepaper demonstrates the High Performance Liquid Chromatography (HPLC) separation and analysis technique and highlights the importance of using water of sufficient purity as an eluent and how the arium® pro VF system can facilitate this.
Application note: Cleaning validation from HPLC to TOC: three factors to consider
25 April 2019 | By SUEZ
This application note from SUEZ outlines the factors that companies should consider when choosing their cleaning validation procedure, highlighting the benefits of TOC analysis over HPLC.
Don’t let difficult substances control your cleaning validation
18 April 2019 | By SUEZ
TOC analysis is a widely adopted method for detecting residual product or cleaning agents on manufacturing equipment. Compared to specific methods such as HPLC, TOC can provide better process understanding and efficiency for cleaning validation (CV), verification and continuous monitoring...
Project launched to tackle lab inefficiency, support AI adoption
12 March 2019 | By Nikki Withers (European Pharmaceutical Review)
A project backed by major pharma will advance the Lab of the Future with proof of concept software to digitise experiment methods…
HPLC Workflow solutions
13 December 2018 | By Merck Millipore
Instrument agnostic consumables available for an HPLC or LC-MS workflow lab.
No Doubts with your drug development
13 December 2018 | By Merck Millipore
Cross checking your HPLC method for impurity profiling with TLC.
Application Note: Real time, low flow, pharmaceutical soil cleanability profiling with TOC and conductivity
12 December 2018 | By SUEZ
Designing a robust cleaning process for pharmaceutical drug manufacturing is critical to successful cleaning validation and verification.
Scientific Poster: How complementary chromatographic methods can support a full analytical picture in pharmaceutical drug development
12 December 2018 | By MilliporeSigma
HPLC is a rapid, accurate and sensitive method for determination of pharmaceutical drugs, degradations and impurity profiling. It is a preferred method for analytical characterisation during drug development.
Application Note: Streamlined purification of assay‑ready oligonucleotides by automated HPLC
19 November 2018 | By Gilson
Oligonucleotides must be of high purity when used in molecular biology applications, but efficient purification over a large range of production scales is challenging. The Gilson GX-271 Oligonucleotide Purification System provides a versatile solution for continuous separation, analysis, and desalting of oligonucleotides...