Application note: Ultrapure water for LC-MS biomedical analyses
In this paper the suitability of reagent water for LC-MS biomedical analyses will be evaluated and the role of water quality in achieving sensitive and reliable LC-MS analyses will be discussed.
Furthermore, since quality assurance is one of the key requirements in the clinical laboratory, a modern solution for data management will be introduced in order to address this need.
The power of LC-MS is recognized by biomedical laboratories worldwide. Nowadays modern LC–MS instrumentation ranges from research to routine use in clinical laboratories and is effectively applied in such areas as:
- Therapeutic drug monitoring – measure of drugs (e.g., immunosuppressants) in plasma, blood or tissues
- Drugs of abuse testing – measure of drugs (e.g., cannabis, methadone, amphetamine, morphine, meperidine,
etc.) in urine or saliva
- Hormone testing – measure of hormones (e.g., steroids or thyroid hormones) in serum or plasma
- Biogenic amine analysis – measure of biogenic amines (e.g., catecholamines) in plasma or urine
- Neonatal screening – detection of treatable disorders in infants by monitoring amino acid and acylcarnitine
levels using LC-MS