Article: Tips & tricks: sensitivity gains in LC-MS
The prerequisite of any highly sensitive analysis via HPLC-MS (high performance liquid chromatography coupled to mass spectrometry) is the use of ultrapure solvents and reagents and careful handling of all associated materials, consumables, and systems.
This prevents any contamination throughout the entire sample handling process from preparation to MS detection, and improves sensitivity.
In the following sections, various measures and options for maximized LC-MS sensitivity and low limit of detection (LOD) are shown. Each and every tip avoids contaminations causing signal suppression, adduct formation, elevated background noise and increased spectrum complexity.
Please read and download the full Article below:Tips Tricks- Sensitivity Gains in LC-MS
Related content from this organisation
- Short talk: How EN 17141 impacts active air sampler validation
- Whitepaper: Progress in LC-MS-based metabolomics techniques
- Whitepaper: Neutralizers of disinfectants in culture media
- Web portal: Check your elemental impurity according to ICH Q3D guidelines
- Building the UK’s domestic pharma manufacturing capability