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Article: Tips & tricks: sensitivity gains in LC-MS

Posted: 2 July 2019 | | No comments yet

The prerequisite of any highly sensitive analysis via HPLC-MS (high performance liquid chromatography coupled to mass spectrometry) is the use of ultrapure solvents and reagents and careful handling of all associated materials, consumables, and systems.


This prevents any contamination throughout the entire sample handling process from preparation to MS detection, and improves sensitivity.

In the following sections, various measures and options for maximized LC-MS sensitivity and low limit of detection (LOD) are shown. Each and every tip avoids contaminations causing signal suppression, adduct formation, elevated background noise and increased spectrum complexity.

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