QA/QC & Analytical Techniques In-Depth Focus 2021

Posted: 17 February 2021 | | No comments yet

Read this in-depth focus to find out how moisture affects the performance of NIR spectroscopy-based classification models and discover novel mass spectrometry applications for pharmaceutical R&D.

EPR - Issue 1 2021 - QA/QC IDF

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    • Effect of moisture variation on the robustness of NIR spectroscopy-based calibration models
      NIR spectroscopy is well-known for its sensitivity to water, which can be useful for detecting water variation in the sample matrix. However, for many other applications, water intake of the samples may be an issue and must be closely monitored to gauge the predictive performance of calibration models. This article looks at how moisture fluctuations in drug products affect the performance of classification models. To achieve this, we built hit quality index (HQI) and principal component analysis (PCA) identification models on pharmaceutical finished products to see how humidity variations affect the robustness of these models.
    • Established and new mass spectrometry applications to drug discovery and development
      Mass spectrometry has numerous applications in pharmaceutical research, from initial discovery through to characterisation and quality control. In this article, Dr Ioannis Papayannopoulos details the role of mass spectrometry in pharma R&D by highlighting established and novel applications of the technique in drug discovery and development.