The obstacle to developing an optimum placebo formulation for pharmaceutical freeze drying
Scale-up of pharmaceutical freeze-drying processes is cost and time consuming due to Quality by Design (QbD) requirements and novel compound costs or availability. The application of placebo formulations offers a promising way to improve drug development activities and save resources. Furthermore, placebos are used as a reference in clinical trials. However, there are obstacles to the development of placebo formulations regarding both intended uses.
Use of placebos in pharmaceutical freeze drying
The objective of the development phase of freeze dried pharmaceutical products is to achieve efficient processes and final products with high quality and stability.1 To achieve this aim, one needs to perform several experimental runs to develop an optimum formulation and robust cycle.2-4
The rest of this content is restricted - login or subscribe free to access
Thank you for visiting our website. To access this content in full you'll need to login. It's completely free to subscribe, and in less than a minute you can continue reading. If you've already subscribed, great - just login.
Why subscribe? Join our growing community of thousands of industry professionals and gain access to:
- bi-monthly issues in print and/or digital format
- case studies, whitepapers, webinars and industry-leading content
- breaking news and features
- our extensive online archive of thousands of articles and years of past issues
- ...And it's all free!