Maximising the efficiency and application of automated planar patch clamp electrophysiology
21 September 2007 | By Paul J Groot-Kormelink PhD, Pamela R Tranter PhD and Martin Gosling PhD, Novartis
The widespread expression of ion channels and their ability to significantly modulate cell function makes them attractive drug targets1. Therapeutic agents which target ion channel proteins comprise the third best selling class of prescription drugs with US sales in 2002 estimated at $12 billion. Somewhat surprisingly the discovery of many…