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4-in-1 vaccine may provide lifelong protection against influenza
A vaccine combining centralised ancestral genes from four major influenza strains appears to provide broad protection against influenza...
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Combined therapies increase side effects for patients with advanced breast cancer
Patients with advanced breast cancer who are treated with a combination of drugs are at increased risk of suffering adverse side effects...
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Balancing the efficacy and safety of preservatives in multidose products
The EMA recently introduced labelling requirements for some common excipients based on an in-depth assessment of their safety profiles, particularly in the paediatric population.1 This article considers their use in multidose products...
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Nusinersen enables infants with SMA to regain motor function
Infants with SMA are more likely to show gains in motor function and survive without assisted support when treated with nusinersen...
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Topical valsartan found to be effective in accelerating chronic wound healing
A topical gel made from a class of common blood pressure medications has been found to accelerate the healing process of chronic skin wounds...
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Long-term use of PPIs linked to stomach cancer
The long-term use of proton pump inhibitors, a class of drugs commonly used to treat acid reflux, is linked to the risk of developing stomach cancer...
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Systematic review looks at the effectiveness and side effects of mefloquine
Researchers have published two systematic reviews revealing the safety of mefloquine for preventing malaria in travellers...
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Smart artificial beta cells could lead to new diabetes treatment
Researchers have designed synthetic beta cells that secrete insulin in response to high blood sugar...
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FDA approves new dosing for Xarelto to reduce the risk of VTE
The FDA has approved the 10 mg once-daily dose of Xarelto, for reducing the continued risk of recurrent venous thromboembolism...
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New treatments help those with mild, moderate and severe eczema
Crisaborole and dupilumab approved for atopic dermatitis…
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New initiative to accelerate development of universal influenza vaccines
Universal Influenza Vaccine Initiative will address the underlying scientific barrier impeding the development of broadly protective, universal influenza vaccines...
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Sandoz proposed biosimilar pegfilgrastim accepted by EMA
Sandoz has announced that its biosimilar pegfilgrastim has been accepted by the EMA for regulatory review...
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Researchers identify ineffectiveness of Alzheimer’s drug semagacestat
Scientists have found that some potential γ-secretase inhibitors such as semagacestat, do not function as true inhibitors as originally expected...
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Design, formulation and manufacture of film-coated drug products
Film coating is a common step in tablet manufacture that can be used to improve product appearance, organoleptic properties, or to facilitate swallowing. Functional film coats can also be used as a part of the product’s stabilisation strategy and to modify or delay drug release.
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The importance and efficacy of epigallocatechin and epicatechin
Plant extracts have been used in African folk medicine to treat a wide array of infections, especially in Nigeria, for centuries. This article considers the potential medicinal uses and efficacy of the flavonoids epigallocatechin and epicatechin, which can be extracted from the Spondias mombin plant.
