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The evolution of antibody-drug conjugates (ADCs) is a spectacular example of how global research can sculpt a new technology. Years of molecular and cell biology, conjugation chemistry and immunology progress has enabled a cytotoxic agent paired with a tumour-specifi c antibody to become mainstream cancer therapy.1 Today, advances continue, explains…
Instrument agnostic consumables available for an HPLC or LC-MS workflow lab.
The rapid increase in demand for biopharmaceuticals presents manufacturers with unique challenges to ensure quality and regulatory compliance while maintaining supply and production capacity.
The purpose of process development in pharma is to select and optimise a synthetic route to produce the active pharmaceutical ingredient (API) by the safest, cheapest, fastest, and cleanest (by green chemistry where possible) route, following both Good Laboratory Practice (GLP) and Quality by Design (QbD) principles.
HPLC is a rapid, accurate and sensitive method for determination of pharmaceutical drugs, degradations and impurity profiling. It is a preferred method for analytical characterisation during drug development.
For several decades mass spectrometry (MS) has been used in the characterisation of protein pharmaceuticals.1-3 However, its use in the laboratory for quality control (QC) product release testing has been quite limited for a number of reasons, for example: instrument complexity and software are not readily amenable to validation, extensive…
This In-Depth Focus examines methods to improve efficiency on the production line and explores a LC-MS based multi-attribute method for characterisation and QC testing of protein therapeutics.
Peak Scientific, the global leader in gas generation for analytical laboratories, has introduced a new hydrogen gas solution to the market, the Precision Hydrogen Trace 1200...
Infliximab, commercially known as Remicade, is a chimeric IgG1 kappa monoclonal antibody (mAb), that targets tumor necrosis factor-alpha (TNF)....
Peak Scientific, the global leader in gas generation for analytical laboratories, has today introduced a new nitrogen gas solution to the market, Genius SQ 24...
Shimadzu, one of the world's fastest growing mass spectrometry companies and Protein Metrics Inc., a leading provider of mass spectrometry software for protein characterisation, today announced a co-marketing agreement for the use of Byos™ with Shimadzu Q-TOF technology...
Redefines Lipidomics and Glycomics Research with Shimadzu's LCMS-9030 Q-TOF Mass Spectrometer...
Shimadzu, one of the world's fastest growing mass spectrometry companies, announces the launch of the quadrupole time-of-flight (Q-TOF) LCMS-9030 system...
Thermo Fisher Scientific Inc., the world leader in serving science, today unveiled advances in its leading mass spectrometry portfolio that make these powerful technologies more accessible to scientists across life sciences and applied markets...
Improving the accuracy and user-friendliness of mass spec technologies to enable critical decisions in safety, healthcare and nutrition...
