Liquid chromatography mass spectrometry (LC-MS) is a highly accurate and sensitive platform used in biopharmaceutical research and development.
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Genotoxic impurities (GTI’s) are intermediate, reactive products or degradants formed during drug synthesis, formulation or storage.
Building from the company’s best-selling SCIEX Triple Quad™ for over 10 years, users can now get triple quad sensitivity plus QTRAP® functionality in one system.
Application Note: Sensitive quantitation of the ADC ado-trastuzumab emtansine free cytotoxic drug DM1 in serum using MicroLC-MS
Antibody-drug conjugates (ADC’s) are targeted cancer therapeutics that deliver a cytotoxic agent, the payload, to the tumour.
Application Note: Highly selective bioanalytical quantitation method for analysis of R and S amlodipine enantiomers in human plasma using LC-MS/MS
Amlodipine is an angioselective calcium channel blocker used to treat high blood pressure, chest pain and other conditions caused by coronary artery disease.
Application Note: Simultaneous quantitation/profiling of cell culture medium components using LC-MS/MS
Multi-component methods for the detection of different compound classes, such as vitamins and amino acids, have been established and are widely used to analyse a broad range of samples.
A complete workflow to quantify intact therapeutic proteins in plasma matrix has been developed, covering three critical components in preclinical sample analysis: target protein enrichment/purification, LC/MS data acquisition and quantitative data analysis.
Improving the accuracy and user-friendliness of mass spec technologies to enable critical decisions in safety, healthcare and nutrition...
SCIEX announces new BioPharmaView Software 3.0 for streamlining multiple-attribute methodology (MAM)
Complete and easy-to-use LC-MS-based solution for biotherapeutics characterisation and quality testing...
SCIEX OS 1.4 launches with next-generation algorithms and complete data processing compatibility across SCIEX mass spectrometry platforms
New software offers improved workflow efficiency with enhanced data management and the tools to support 21 CFR Part 11 compliance across the SCIEX mass spectrometry portfolio...
Whitepaper: Enabling single-software multiple attribute methodology (MAM) for assessment of biopharmaceutical product quality attributes
Application of BioPharmaView™ 3.0 Software for a Streamlined MAM Workflow...