Whitepaper/App Note

Application Note: A new crystallinity gauge: Real-time quantification and monitoring of crystallinity in pharmaceuticals

Posted: 14 December 2017 | | No comments yet

Ondax app note image

The measurement and quantification of crystallinity in pharmaceuticals is of vital importance, as this has a direct influence on the solubility and stability of the final drug product, affecting both efficacy and expiration…

Both environmental factors (e.g temperature, humidity) and manufacturing processes (e.g. grinding, milling, freeze drying) can dramatically affect crystal formation and/or breakdown into amorphous forms, and these processes are often dynamic on much faster timescales than most measurements can be taken. Therefore, having fast, reliable methods that can provide unambiguous determination of crystalline content is essential for chemical process development, formulation, stability testing and material characterisation. 

To date, there has been a lack of process analysis instruments that can provide both adequate sensitivity and a timely response for measurements and monitoring of crystalline content. A new Raman-based platform that provides real-time crystallinity measurements with superior sensitivity is now available.

This whitepaper is restricted - login or subscribe free to access

european pharmaceutical review magazine cover issue 2 2018Thank you for visiting our website. To access this content in full you'll need to login. It's completely free to subscribe, and in less than a minute you can continue reading. If you've already subscribed, great - just login.

Why subscribe? Join our growing community of thousands of industry professionals and gain access to:

  • bi-monthly issues in print and/or digital format
  • case studies, whitepapers, webinars and industry-leading content
  • breaking news and features
  • our extensive online archive of thousands of articles and years of past issues
  • ...And it's all free!

Click here to Subscribe today Login here

 

Leave a Reply

Your email address will not be published. Required fields are marked *

Send this to a friend