Whitepaper/App Note

Scientific Poster: From Screening to Small Scale GMP Biomanufacturing: Exploring a simple, unified platform strategy for handling a range of cell culture needs

Posted: 26 June 2018 | | No comments yet

This poster discusses a process for a 12-week clone development process. The process starts in silico, and progresses through screening and clone selection in 96-deepwell plates up to five liter shaker flasks…

Machine learning and protein engineering make it fast and easy to generate large numbers of high expressing stable cell lines. Such cell lines are moving biomanufacturing from mega-scale towards smaller efficient processes. To select the best of many candidates, tools for clone screening, selection and scaling up have become more important than ever. The ready availability of high-expressing cell lines makes it possible to use incubation shakers instead of bioreactors for many bioproduction needs. Incubation shakers are already standard issue for cell line screening and development. They therefore provide a simple and easily validated path from clone screening all the way to cGMP manufacturing.

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