Application note: Advancing diagnostics and treatment with Raman imaging
With confocal Raman imaging the molecules of a sample can be chemically identified and their distribution can be imaged three-dimensionally...
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Whitepapers & App Notes
Whitepaper: Development of an Efficient Manufacturing Process for Adenovirus
Large-scale downstream processing of viruses for clinical applications poses challenges different from those for many other biotherapeutics. These challenges mostly arise from the size and complexity of the virus...
Whitepaper: Raman-Based Endpoint Detection of a Heterogeneous Etherification Reaction
Raman spectroscopy has been successfully integrated in laboratory, pilot, process development and GMP manufacturing environments. Find out how it was used at the pilot scale to detect the endpoint of a heterogeneous etherification reaction...
Application note: Raman spectroscopy to study the distribution of compounds in a pharmaceutical drug product
In this application note, HORIBA discuss using raman spectroscopy to study the distribution of compounds in pharmaceutical drug products...
Poster: Accelerate antibody drug development with subdomain-specific affinity ligands
Scientists from Thermo Fisher Scientific discuss how the CaptureSelect affinity purification products and analytical tools have been developed for the discovery and manufacturing of therapeutic antibodies, including novel formats such as bi-specific antibodies and Fc-fusion proteins...
Poster: Polyvinyl alcohol in hot melt extrusion to improve the solubility of drugs
This poster evaluates a pharmaceutical grade polyvinyl alcohol (PVA) as the matrix polymer for HME application...
Poster: Microbial survival in compressed gases under fast decompression to normal atmospheric conditions
This scientific poster reviews numerous scientific literature related to microbial survival under a broad range of environmental pressure conditions, and the resilience of microorganisms under variable compression and decompression environments.
Poster: Prevention of dose dumping in PVA-based directly compressed sustained-release matrix tablets
This poster investigates the influence of a directly compressible polyvinyl alcohol (PVA) tablet matrix on the in-vitro drug release that occurs in media of various pH values or alcohol concentrations...
Application note: Rapid identification of illicit drug substances using thermal desorption coupled with a portable toroidal trap GC/MS system
This study describes the injection, separation, and identification of 16 drugs compounds in less than 10 minutes using portable gas chromatograph-toroidal ion trap mass spectrometry (PerkinElmer, Torion® T-9 Portable GC/MS) combined with a coiled-wire-filament (CWF) sampling injector to provide an effective tool for onsite analysis of illicit drugs substances...
Whitepaper: Looking beyond analytical data standardization – the Fourth Paradigm
This paper provides commentary on efforts for analytical data standardization and a vision of the broader considerations and requirements that such an undertaking should include...
Whitepaper: Extractable and leachables studies – designed and performed to meet all intended needs
Following FDA legislation in 1999, scrutinising packaging standards for extractables and leachables has become the norm. In this whitepaper, Eurofins examines the ways in which the evaluation of final packaging components is now carried out including the role of liquid and gas chromatography-mass spectrometry in the process.
Poster: Combining spectroscopy and critical process parameters for monitoring continuous tablet manufacturing via multivariate data analysis
CAMO Software discuss how combining spectroscopy and critical process parameters can assist in monitoring continuous tablet manufacturing...
Poster: Optimised purity and recovery of a monoclonal antibody using mixed-mode chromatography media
Bio-Rad discuss the technique of optimising the purity of a monoclonal antibody using mixed-mode chromatography media...
Poster: micro-Matrix – Screening of feeding strategies based on trigger events in a 24-micro bioreactor platform
Applikon Biotechnology discuss how the micro-Matrix has been used to study feed strategies
Whitepaper: Bacterial identification database
This whitepaper examines the Eurofins Microbial Sequencing Index (EMSI) database which contains over 9,000 full gene sequences of type strains and explains why reliable analytical methods are so vital in microbiology...
