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Large-scale downstream processing of viruses for clinical applications poses challenges different from those for many other biotherapeutics. These challenges mostly arise from the size and complexity of the virus...
Raman spectroscopy has been successfully integrated in laboratory, pilot, process development and GMP manufacturing environments. Find out how it was used at the pilot scale to detect the endpoint of a heterogeneous etherification reaction...
In this application note, HORIBA discuss using raman spectroscopy to study the distribution of compounds in pharmaceutical drug products...
Scientists from Thermo Fisher Scientific discuss how the CaptureSelect affinity purification products and analytical tools have been developed for the discovery and manufacturing of therapeutic antibodies, including novel formats such as bi-specific antibodies and Fc-fusion proteins...
This poster evaluates a pharmaceutical grade polyvinyl alcohol (PVA) as the matrix polymer for HME application...
This scientific poster reviews numerous scientific literature related to microbial survival under a broad range of environmental pressure conditions, and the resilience of microorganisms under variable compression and decompression environments.
This poster investigates the influence of a directly compressible polyvinyl alcohol (PVA) tablet matrix on the in-vitro drug release that occurs in media of various pH values or alcohol concentrations...
This study describes the injection, separation, and identification of 16 drugs compounds in less than 10 minutes using portable gas chromatograph-toroidal ion trap mass spectrometry (PerkinElmer, Torion® T-9 Portable GC/MS) combined with a coiled-wire-filament (CWF) sampling injector to provide an effective tool for onsite analysis of illicit drugs substances...
This paper provides commentary on efforts for analytical data standardization and a vision of the broader considerations and requirements that such an undertaking should include...
Following FDA legislation in 1999, scrutinising packaging standards for extractables and leachables has become the norm. In this whitepaper, Eurofins examines the ways in which the evaluation of final packaging components is now carried out including the role of liquid and gas chromatography-mass spectrometry in the process.
CAMO Software discuss how combining spectroscopy and critical process parameters can assist in monitoring continuous tablet manufacturing...
Bio-Rad discuss the technique of optimising the purity of a monoclonal antibody using mixed-mode chromatography media...
Applikon Biotechnology discuss how the micro-Matrix has been used to study feed strategies
This whitepaper examines the Eurofins Microbial Sequencing Index (EMSI) database which contains over 9,000 full gene sequences of type strains and explains why reliable analytical methods are so vital in microbiology...
The development and production of antibody biopharmaceuticals and biosimilars require specific chromatographic tools for efficient purification and QC analysis to improve process economics, safety, and time-to-market.
