Whitepapers & App Notes

Application note: Enhancing reaction understanding with online NMR reaction monitoring – application to chemical route development

11 January 2016 | By Anna L. Dunn, Analytical Research and Development, Pfizer, Department of Chemistry, University of Wisconsin / Anna Codina, Bruker UK Limited / David A. Foley and Mark T. Zell, Analytical Research and Development, Pfizer

In this work, we demonstrate the complementarity of NMR and infrared (IR) spectroscopy and show the use of NMR to improve the understanding and robustness of the synthesis of an active pharmaceutical ingredient (API) precursor...

Application Note: Direct measurement of challenging target-ligand interactions

11 January 2016 | By GE Healthcare

GE Healthcare’s most sensitive SPR-based sensor enables accurate interaction analysis of LMW fragments binding to difficult targets.

Application Note: A phenotypic assay for metastasis

8 January 2016 | By BioTek Instruments

BioTek demonstrate a method for the generation of 3D spheroidal structures using a co-culture of a human breast cancer cell line and human fibroblasts embedded in an invasion matrix containing CXCL12 as chemoattractant...

Whitepaper: Enhanced Raman reflection spectroscopy for process analytical technology

1 December 2015 | By Kaiser Optical Systems

This note describes the use of enhanced Raman reflection spectroscopy to accomplish analysis on multi-layered samples similar to many pharmaceutical tablets...

Poster note: MALDI high-throughput screening beyond 100,000 samples per day in drug discovery

17 November 2015 | By Bruker, Novartis

This work focuses on the improvement of MALDI-TOF automation parameters to further increase sample analysis speed in HTS assays to more than 100,000 samples per day...

Application note: Raman monitoring of active coating composition

1 November 2015 | By Kaiser Optical Systems

This application note demonstrates the suitability of Raman spectroscopy using Kaiser’s unique noncontact large-spot PhAT technology to monitor of active coating composition.

eBook: Pharma Serialisation – Where to Begin

1 November 2015 | By TraceLink

By the end of 2018, 75% of the world’s prescription medications will be protected by legislation - this eBook explains the basic fundamentals of pharma serialisation...

Whitepaper: Development and optimization of CHOgro® transient expression technologies for high titer antibody production in suspension CHO cells

1 October 2015 | By Mirus Bio

During early stage drug development, quickly obtaining relevant candidate proteins through transient transfection can accelerate drug discovery.

Whitepaper: Multiplexed cancer immune response analysis nCounter® PanCancer Immune Profiling Panel for gene expression

1 October 2015 | By nanoString

The ability of mutated cells to give rise to pathological cancer relies upon the capability of these cells to evade immune recognition, suppress immune activity, and persist in a chronically inflamed environment. Tremendous growth in the understanding of these complex processes is beginning to generate breakthroughs in the treatment of…

Application note: High-throughput Screening of Deubiquitylase enzyme (DUB) activity/specificity and inhibitor screening by MALDI-TOF mass spectrometry

1 September 2015 | By Bruker

In biopharmaceutical laboratories, there is a growing need for high-throughput, yet sensitive methodologies to characterize deubiquitylase enzymes (DUBs) and DUB inhibitors...

Whitepaper: Current trends in Raman Spectroscopy for Upstream Bioprocess Monitoring and Control

1 September 2015 | By Kaiser Optical Systems

This application note covers some new trends in bioprocess monitoring and control focusing on the increasing use of Kaiser Optical Systems Raman spectrometers as multi-measurement bioprocess sensors to enable quality by design, process optimization, process control and continuous processing...

Case Study: Perceptive Engineering

3 July 2015 | By Perceptive Engineering

Perceptive Engineering discusses a two year collaborative R&D project it undertook to address challenges associated with the new generation of reactor systems used in production...

Whitepaper: Analysis of a Mammalian cell culture

1 July 2015 | By Kaiser Optical Systems

In this free whitepaper we discuss real-time, in situ bioprocess understanding in accordance with the PAT initiative and comparison of Raman and NIR spectra of cell culture components...

Application note: Aseptic identification of polysorbates using handheld Raman

1 April 2015 | By Rigaku

Polysorbates are used in a variety of industries including food, cosmetics, pharmaceuticals and biopharmaceuticals – specifically in the manufacturing of parenteral medication and cell culture growth.

Application Note: Drug product identification using Handheld Raman

5 March 2015 | By Rigaku

This Application Note from Rigaku discusses the use of Handheld Raman spectroscopy for raw material and excipient identification within the pharmaceutical industry.