Solid- and Liquid-State NMR for monitoring of polysaccharide antigen in the manufacturing process
Posted: 25 June 2021 | Francesco Berti (GSK Vaccines) | No comments yet
Francesco Berti, Scientific Director at GSK Vaccines – Siena, Italy, reveals how NMR spectroscopy tools are invaluable in vaccine production.
PHYSICOCHEMICAL technologies have been demonstrated to be powerful tools for the structural characterisation of vaccines. Modern technologies, such as Nuclear Magnetic Resonance (NMR) spectroscopy, are today crucial to vaccine characterisation.
In this article, Francesco Berti discusses how NMR can be used to track the identity and structural integrity of antigens along the entire vaccine manufacturing process. He also explains how this can prevent unexpected modifications that might impact the quality of the vaccines and uses a meningococcal serogroup A polysaccharide antigen in the production process of a quadrivalent vaccine to demonstrate the point.
Issue
Related topics
Analytical techniques, Biologics, Formulation, Nuclear Magnetic Resonance (NMR) spectrometry, QA/QC, Spectroscopy
