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Nuclear Magnetic Resonance (NMR) spectrometry

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How can NMR spectroscopy help protein biopharmaceutical development?

24 February 2020 | By ,

Nuclear magnetic resonance (NMR) spectroscopy is a technique that most have heard of but many avoid, especially when dealing with larger biological macromolecules. Why? The common wisdom is that NMR can be complicated, expensive and involves quantum physics and complex equations. In the fast-paced industrial biopharmaceutical environment there may be…


NMR-based fragment screening for drug discovery

8 February 2017 | By Bruker Biospin

An introduction to Bruker’s newly launched FBS tool that works with TopSpin software: how it helps to greatly accelerate data analysis during NMR-based FBS by incorporating all screening data into one place and automating many of the processes that are usually done manually...

Whitepapers/App Notes/Posters

Application note: Enhancing reaction understanding with online NMR reaction monitoring – application to chemical route development

11 January 2016 | By Anna L. Dunn, Analytical Research and Development, Pfizer, Department of Chemistry, University of Wisconsin / Anna Codina, Bruker UK Limited / David A. Foley and Mark T. Zell, Analytical Research and Development, Pfizer

In this work, we demonstrate the complementarity of NMR and infrared (IR) spectroscopy and show the use of NMR to improve the understanding and robustness of the synthesis of an active pharmaceutical ingredient (API) precursor...


Fast quantitative 2D NMR for quantifying analytes in complex mixtures

3 July 2015 | By Patrick Giraudeau, University of Nantes

Nuclear magnetic resonance (NMR) spectrometry is a major quantitative tool in pharmaceutical analysis, owing to its extremely high accuracy. However, absolute quantification in complex mixtures is often hampered by spectral overlap which considerably reduces the quantitative performance of NMR.