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Formulation, Development & Delivery In-Depth Focus 2018

In this In-Depth Focus; early biotherapeutic lead optimisation for more efficient drug discovery and development, and turning promising compounds into drug candidates.

Drug formulation, development and delivery in-depth focus issue 2 2018
  • Early biotherapeutic lead optimisation for more efficient drug discovery and development
    Lead optimisation for discovery of small molecule drug candidates is well established, but less so for biological drug candidates. While biologics are much easier to modify than non-natural small molecules, via the introduction of changes in their amino acid sequence through genetic engineering technologies, this approach is frequently met with trepidation.
  • The path to clinic: turning promising compounds into drug candidates
    Turning a promising preclinical compound into a drug candidate that is fit for first-in-human (FIH) trials is a complex, multi-stage process requiring expertise in formulation development and clinical trial management.

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