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Addressing kinetic applications in High Content Screening

29 September 2008 | By

Traditional drug discovery screening assays tend to employ simplistic endpoint assays that often monitor the activity of a single target. While these approaches are amenable to high-throughput screening they provide limited information on how candidate drugs influence complex biological systems that exist in vivo. Such limitations are a contributing factor…

Human Embryonic Stem Cells: Progress in culture and maintenance

29 September 2008 | By

The pharmaceutical industry is at a crossroads: Research and Development costs continue to rise, whilst the pipeline of ‘blockbuster’ drugs is looking decidedly sparse for many of the major pharmaceutical companies. This state of affairs is compounded by the high attrition rates (>80%) of drug candidates, when they get to…

Europe’s leading biotech industry event

29 September 2008 | By

BIOTECHNICA in Hannover is the leading event within the European biotech industry. It embraces every segment of biotechnology - from basic biotechnology and equipment, bio-informatics and services to the five major areas of application...

Recent development in Rapid Microbiology Methods

29 September 2008 | By

Microbiology is the scientific study of micro-organisms and includes many sub disciplines like bacteriology, virology, mycology, and parasitology: all characterized by the study of organisms too small to be seen by the naked eye. This defining aspect has determined the focus of microbial research over the last century: the need…

A significant comparison between collapse and glass transition temperatures

29 September 2008 | By Eva Meister and Dr. Henning Gieseler, Division of Pharmaceutics, University of Erlangen-Nuremberg

Rational freeze-drying process design is based on a representative and accurate measurement of the critical formulation temperature. To avoid product shrinkage or collapse, it is indispensable to control the product temperature just below this key temperature during primary drying. Over the last decades, DSC was routinely used to determine the…

Successful Process Analytical Technology (PAT) implementation in pharmaceutical manufacturing

29 September 2008 | By Thirunellai G. Venkateshwaran (Senior Director, New Products Quality, Global Quality and Compliance), John Levins (Senior Director, Technology Transfer & Process Innovation) and Stephen P. Simmons (Head of New Product Quality and Quality by Design), all Wyeth Pharmaceuticals

The use of Process Analytical Technology (PAT) while a relatively new concept to the Pharmaceutical Industry has been a tried and tested concept in the petrochemical industry for many years. The adaptation of PAT systems by the Pharmaceutical Industry was accelerated by the recent initiatives of the regulatory authorities globally…

Product and Process Optimization

29 September 2008 | By

The Università Degli Studi di Siena, Dipartimento Farmaco Chimico Tecnologico; Societa' Chimica Italiana, Divisione di Chimica Industriale; Center for Process Analytical Chemistry at the University of Washington, Seattle; and IFPAC have planned an exciting conference on Process and Product Optimization to be held from 5-8 October 2008 at the Certosa…

P-MEC Europe: where technology meets ambition

29 September 2008 | By

The Pharmaceutical Machinery and Equipment Convention, P-MEC was first held in Madrid in 2005 and has since rapidly grown into a must-attend event for both sellers and buyers of pharmaceutical processing and manufacturing equipment.

RNAi therapeutics: addressing targets?

2 August 2008 | By

Gene silencing by RNA interference (RNAi) uses double-stranded RNA to shut down gene expression in cells. This provides the possibility that this new methodology could be used in the treatment of disease symptoms and disease processes. A particular attraction of RNAi (as well as other gene knockdown methods of treatment,…

Real-time quantitative PCR – opportunities and pitfalls

2 August 2008 | By

The emergence of next generation sequencing technology has brought the prospect of digital analyses closer, technology that will allow not just the quantification of nucleic acids, but will result in the fine-tuning of this information with respect to tissue- and cell-specific transcription, the identification of new transcriptional units, e.g. the…

RNAi Europe & Advances in qPCR

2 August 2008 | By

From 16-18 September 2008, and to be held in Stockholm, Sweden, Select Biosciences invites you to the 5th annual RNAi Europe – Europe's largest conference & exhibition dedicated to RNA interference. It will also be conveniently co-located with Advances in qPCR conference and exhibition.

7th HUPO World Congress

2 August 2008 | By

The 7th World Congress of the Human Proteome Organisation, HUPO, will be held at the RAI Congress Centre in Amsterdam, the Netherlands, from 16-20 August 2008.

Accessing stem cells via proteomics

2 August 2008 | By

Stem cells have two important characteristics that distinguish them from other cells: the ability to self-renew through cell division for a prolonged period, and to differentiate into multiple cells with specialised functions. The power of stem cells for tissue development, regeneration and renewal has been well known to embryologists for…

HUPO 2008 – Proteome Biology

2 August 2008 | By

The theme of the meeting is “Proteome Biology”. In spite of the amazing complexity of the proteome, the field of proteomics has matured to a degree where significant progress in biology and medicine can be realised. This expectation is based on rapid progress in the development of powerful proteomics technologies…