Applying PAT in Chemical Process Development
29 May 2009 | By
As the time-to-market of pharmaceutical products has elongated, while its prices are under big pressure, cost saving is currently essential in the pharmaceutical industry.
List view / Grid view
Articles
Small non-coding RNAs as therapeutics
20 March 2009 | By
For years biologists have worked to develop alternatives to traditional therapeutics. These efforts, in areas such as stem cell based and gene therapies, have received much fanfare in popular media outlets, raising expectations among the general public. This excitement may have contributed to the hasty progression of early gene therapy…
Article 2: Reverse Transcription – a necessary evil
20 March 2009 | By
The fluorescence-based quantitative real-time polymerase chain reaction (qPCR)1-3, is the most widely used method to detect and measure minute amounts of DNA in a wide range of samples extracted from numerous sources. Since all currently available thermostable polymerases are DNA-dependent, RNA must be converted ("reverse transcribed") into DNA prior to…
The Data Cave: A collaborative method for interpreting genomic data
20 March 2009 | By
Generating knowledge and insight from complex genomic data sets is always a challenging endeavor. As data collection becomes more routine and less expensive, and the existing body of data expands, getting the most out of genomics experiments requires ever more expertise and insight. Here, we discuss our method of integrating…
Stem Cells Roundtable
Dr Paul Andrews (Senior Scientist, ITI Stem Cell Technology Programme, University of Dundee), Professor Peter Andrews (co-Director of the Centre for Stem Cell Biology, University of Sheffield), Fergus McKenzie PhD. (Programme Manager, ITI-Life Sciences), Dr Stephen Minger (Senior Lecturer in Stem Cell Biology, Kings College London) and Will Rust (Section…
High content screening and analysis
20 March 2009 | By
Technological advances in robotised microscopy, liquid handling and image processing have enabled the emergence of high content screening where large numbers of specimens are automatically analysed. Here we overview the process discussing potential difficulties and solutions.
Development and implementation of an automated compound screening activities facility
There has been a continuous move by the large commercially orientated players involved in Drug Discovery to initiate novel methods to increase income streams and productivity. An example of the former has been the acquisition of companies and their drug pipelines and in the case of the latter, rationalisation of…
SBS 15th annual conference and exhibition
20 March 2009 | By
The 15th annual SBS conference and exhibition will be held in Lille, the capital of the Nord-Pas-de Calais region in Northern France. 2009 is a momentous year for SBS as it is the 15th anniversary of the formation of the Society and to celebrate the occasion this year's theme will…
The determination of structural changes of biopharmaceuticals during Freeze-Drying using Fourier Transform Infrared Spectroscopyb
Peptides and proteins are powerful active therapeutic ingredients used in a wide variety of serious conditions and illnesses such as diabetes, arthritis or cancer. The application of these so-called biopharmaceuticals has been rapidly increasing since the middle of the 1990s, facilitated by improvements in modern recombinant DNA technology and biotechnological…
CIA 2009 overview
20 March 2009 | By
On the cold and snowy weekend of the 7th and 8th of February a group of academics, professionals and vendors met in Dublin for the first Cellular Imaging and Analysis event co-hosted by Trinity College Dublin and the European Pharmaceutical Review. Battling through the adverse weather conditions, delegates and speakers…
Quality risk management and the economics of implementing rapid microbiological methods
Quality risk management (QRM) is an important part of science-based decision making which is essential for the quality management of pharmaceutical manufacturing1. The ICH Q9 guideline, Quality Risk Management2 defines QRM as a systematic process for the assessment, control, communication and review of risk to the quality of drug product…
An international exhibition on Chemical Engineering, Environmental Protection and Biotechnology
20 March 2009 | By
Back for the 29th time, Achema 2009 will be the worldwide leading event for chemical engineering and the process industries. With 4,000 exhibitors from every continent, 180,000 participants from 100 countries and 30,000 executives, it is set to be a huge affair. Some of the exhibitors include:
The 57th ASMS Conference on Mass Spectrometry
20 March 2009 | By
The program will begin on Sunday 31 May with tutorial lectures at 5pm and the opening session and plenary lecture at 6.45pm. The tutorial lectures will be given by:
miRNA and viral infections in vertebrates
7 February 2009 | By
For plants and invertebrates, RNA interference is firmly established as an important antiviral mechanism. Even before Fire, Mello, and co-workers described RNA interference (RNAi) in worms in 19981 it was becoming clear that plants have an RNA-dependent pathway that protects against viral infections2. The pathway, then termed post-transcriptional gene silencing…
The importance of sample quality for qPCR
7 February 2009 | By Tania Nolan, Global Manager, Sigma-Aldrich and Stephen Bustin, Professor of Molecular Science, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry
The fluorescence-based quantitative real-time polymerase chain reaction (qPCR)1-3, has the ability to detect and measure minute amounts of DNA in a wide range of samples extracted from numerous sources. In combination with reverse transcription (RT), the use of this technology has revolutionised life sciences, agriculture and medical research4,5. In addition,…
