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29 September 2008 | By
The Pharmaceutical Machinery and Equipment Convention, P-MEC was first held in Madrid in 2005 and has since rapidly grown into a must-attend event for both sellers and buyers of pharmaceutical processing and manufacturing equipment.
2 August 2008 | By
Gene silencing by RNA interference (RNAi) uses double-stranded RNA to shut down gene expression in cells. This provides the possibility that this new methodology could be used in the treatment of disease symptoms and disease processes. A particular attraction of RNAi (as well as other gene knockdown methods of treatment,…
2 August 2008 | By
The emergence of next generation sequencing technology has brought the prospect of digital analyses closer, technology that will allow not just the quantification of nucleic acids, but will result in the fine-tuning of this information with respect to tissue- and cell-specific transcription, the identification of new transcriptional units, e.g. the…
2 August 2008 | By
From 16-18 September 2008, and to be held in Stockholm, Sweden, Select Biosciences invites you to the 5th annual RNAi Europe – Europe's largest conference & exhibition dedicated to RNA interference. It will also be conveniently co-located with Advances in qPCR conference and exhibition.
2 August 2008 | By
European Pharmaceutical Review speaks to Søren Morgenthaler Echwald, Vice President of Business Development at Exiqon regarding new developments in microRNA.
2 August 2008 | By
The 7th World Congress of the Human Proteome Organisation, HUPO, will be held at the RAI Congress Centre in Amsterdam, the Netherlands, from 16-20 August 2008.
2 August 2008 | By
Stem cells have two important characteristics that distinguish them from other cells: the ability to self-renew through cell division for a prolonged period, and to differentiate into multiple cells with specialised functions. The power of stem cells for tissue development, regeneration and renewal has been well known to embryologists for…
2 August 2008 | By
The theme of the meeting is “Proteome Biology”. In spite of the amazing complexity of the proteome, the field of proteomics has matured to a degree where significant progress in biology and medicine can be realised. This expectation is based on rapid progress in the development of powerful proteomics technologies…
2 August 2008 | By
Cell-based assays are essential for drug discovery and development as they increase the quality of lead compounds due to their physiological relevance. Toxicological data can be gathered during the early phases of hit selection and verification, reducing costs and attrition rates during clinical trials.
2 August 2008 | By
What were the drivers that helped launch the laboratory information management system (LIMS) and electronic laboratory notebook (ELN)? This article will trace the history of LIMS and ELN from their emergence into the future. Technology development did play a big role to be sure, but the desire of scientists to…
2 August 2008 | By
Following the highly successful meeting in 2007, the European Laboratory Robotics Interest Group (ELRIG) and the Society of Biomolecular Sciences (SBS), are pleased to announce that their Drug Discovery: 2008 Meeting will be held at the Bournemouth International Centre, (BIC), UK, on 23 & 24 September 2008.
2 August 2008 | By
Chromatin is a nucleoprotein complex, found in eukaryotic organisms, consisting of approximately 50% DNA and 50% histone proteins. The histones undergo a number of reversible covalent chemical modifications (for example, acetylation, methylation, phosphorylation), especially in the N-terminal regions. These chemical changes prepare chromatin for a range of essential cellular processes…
2 August 2008 | By
Differential scanning calorimetry (DSC) is a widely used technique within the pharmaceutical industry because the range of phase transitions it can measure usually allows near complete physical characterisation of a new active principal early during preformulation. In addition, because DSC measures a property change that is ubiquitous† (heat) there are…
2 August 2008 | By
Advanced Aseptic Processing (AAP) is a term referenced in the recently published ISPE RABS definition1 to cover the spectrum of Restricted Access Barrier Systems (RABS) and isolator systems. In general, AAP techniques are physical barrier methods of product protection and containment that are used during manufacturing operations to separate (primarily)…
2 August 2008 | By
Dr. Janet Woodcock’s exhortation (ISPE Annual Meeting, 7 November 2005) that 21st century life science manufacturers should be ‘maximally efficient, agile and flexible’ and produce high quality drug products ‘without extensive regulatory oversight’ has been widely reported as a wake-up call to our industry.
