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PCR In-Depth Focus 2013

25 October 2013 | By

In this PCR In-Depth Focus: Challenges for qRT-PCR in detecting / quantifying microRNA in vitro and in vivo; Emerging clinical applications of digital PCR; Workshop Preview: Advanced 3d cell based assays, preparation, analysis and troubleshooting...

microRNAs and their potential involvement in HIV infection

20 June 2011 | By

Treatment and cure of human immunodeficiency virus-1(HIV-1) infection remains one of the greatest therapeutic challenges due to its persistent infection, often leading to acquired immunodeficiency syndrome (AIDS). Although it has been 28 years since the discovery of the virus, the development of an effective vaccine is still far away. Relatively…

Cancer-secreted microRNAs: Travelers, Messengers, and Blood-borne Biomarkers

22 February 2010 | By Dr John Rossi, Professor and Chair, Division of Molecular Biology and Dean, Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute of the City of Hope and Emily Wang, Assistant Professor, Deptartment of Cancer Biology/Division of Tumour Cell Biology, Beckman Research Institute of City of Hope

Since the first discovery of microRNA (miRNA) from C. elegans in 19931 studies of this new class of regulatory small RNA have grown rapidly and entered a new era, where they now serve as potential biomarkers and therapeutic targets in human diseases, such as cancers. Recent studies indicating that miRNAs…

Small non-coding RNAs as therapeutics

20 March 2009 | By Dr Kevin V. Morris, Assistant Professor, Department of Molecular and Experimental Medicine, The Scripps Research Institute and Peter Hawkins, Graduate student, Kellogg School of Science and Technology, The Scripps Research Institute

For years biologists have worked to develop alternatives to traditional therapeutics. These efforts, in areas such as stem cell based and gene therapies, have received much fanfare in popular media outlets, raising expectations among the general public. This excitement may have contributed to the hasty progression of early gene therapy…

miRNA and viral infections in vertebrates

7 February 2009 | By Pål Sætrom, Post Doctoral Fellow, Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology and Jörn Klein, Post Doctoral Fellow, Department of Computer and Information Science, Norwegian University of Science and Technology

For plants and invertebrates, RNA interference is firmly established as an important antiviral mechanism. Even before Fire, Mello, and co-workers described RNA interference (RNAi) in worms in 19981 it was becoming clear that plants have an RNA-dependent pathway that protects against viral infections2. The pathway, then termed post-transcriptional gene silencing…

Detecting microRNA targets or siRNA off-targets using expression data

3 December 2008 | By Anton J. Enright, Group Leader, EMBL – European Bioinformatics Institute

Recently, small RNAs such as microRNAs (miRNAs) have been demonstrated to be important regulators in both plants and animals. In animals miRNAs act as translational repressors of target genes through a combination of inhibition of translation and mRNA destabilisation. These molecules have been implicated in a multitude of diseases, including…

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