Using a new formulation technique, researchers were able to more than double drug loading of a hydrophobic active pharmaceutical ingredient in tablets. Thus, the new formulation method may lead to smaller pills delivering the same therapeutic benefit.
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In this podcast, Lonza’s Dr Deanna Mudie explains the importance of bioavailability, how to achieve desired bioavailability and top tips for how to select the correct dissolution media for your testing needs.
In this in-depth focus experts provide guidance on how to select starting materials for API's and discuss how to specify exipients to reduce downstream regulatory burdens.
Scientists unveil their model, which other researchers can use to test the injectability of their drug delivering microparticle designs in silico.
Novel particles could be incorporated into topical creams to treat dermatological conditions without systemic exposure to drugs.
High-resolution measurements of particles are of great interest in many fields of application. Combining confocal Raman microscopy with particle analysis tools makes it possible to find, classify and identify particles almost entirely automatically.
The particle size of Active Pharmaceutical Ingredients (API) has a significant effect on a drug product’s manufacturability and performance. With respect to manufacturability, particle size can affect compatibility, flowability and blend uniformity; with respect to product performance it can affect solubility, dissolution, and bioavailability.
Microtrac unveils a new generation of particle analyzers. Microtrac’s Sync is synchronizing size and shape measurement – one sample, one bench, one sample flow path, one sample cell, one analysis...
Malvern Panalytical launches new Morphologically-Directed Raman Spectroscopy system, Benchtop X-ray Fluorescence Spectrometer, and an Automatic Dispensing Balance at Pittcon 2018
Malvern Panalytical, the experts in materials characterization, is pleased to announce the launch of three exciting new systems which will be on display at Pittcon 2018 in Orlando, FL from 27 February through 1 March...
Particle size reduction is a fast and cost-effective answer to increasing the exposure of poorly soluble oral drugs by increasing surface area and thereby improving dissolution rate. This approach will only work for DCS IIa1 drugs where dissolution rate is the rate-limiting factor for absorption. This may be applicable to…
Light-emitting nanoprobes can detect cancer early and track the spread of tiny tumours...
5 September 2016 | By Biopharma Group
Fluid processing requirements are becoming ever more stringent, and so high pressure homogenisation is increasingly surfacing as a solution to meeting these needs...
22 October 2015 | By John Carpenter, University of Colorado / Amber Haynes, Fradkin KBI Biopharma / Christina Vessely, Biologics Consulting Group Inc.
Quantifying and sizing subvisible particles in biopharmaceutical products are crucial aspects of formulation development, stability studies, process development, product release and extended characterisation of the final drug product.