Raman microscopy is well suited to pharmaceutical studies, including the analysis of drug delivery systems and their performance.
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Crystallisation is a common step in the synthesis of organic compounds used to isolate and purify the desired product. As the importance of crystallisation has increased and chemists improve the processes involved, process analytical technology (PAT) tools can be used to design, analyse, and control them. This article considers the…
How the implementation of Exalt™ for evaporative crystallisation studies improves stability and controlled delivery in drug development.
12 July 2016 | By Biopharma Group
Polymorph screening is an important stage of drug development. The aim is to identify the different crystalline structures or polymorphs that a drug may appropriate...
New technique for fast low-level polymorph API quantification using non-destructive transmission Raman spectroscopy
27 May 2016 | By Cobalt Light Systems
A new technique for measuring low-levels of crystalline polymorphic materials offers many advantages over industry standard techniques....
Many organic compounds can crystallize in several different forms called polymorphs. Biologically active polymorphs have different solubility and stability and, hence, different bioavailability. The effectiveness of a drug compound depends critically on its particular polymorph.
22 October 2015 | By Masataka Ito, Kiyohiko Sugano and Katsuhide Terada Faculty of Pharmaceutical Sciences, Toho University
The physicochemical properties of active pharmaceutical ingredients (APIs) are critical to the success of drug development. Most of the APIs in oral solid dosage forms are contained as drug crystals.
The past quarter of a century has seen an enormous increase in the number of papers on the behaviour of the organic solid state, particularly those concerning pharmaceutical polymorphs and solvates. High profile patent cases (ranitidine hydrochloride, paroxetine hydrochloride) combined with product polymorph issues (ritonavir), all of which have carried…