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Applying simple PAT tools to crystallisation in process chemistry

23 October 2017 | By

Crystallisation is a common step in the synthesis of organic compounds used to isolate and purify the desired product. As the importance of crystallisation has increased and chemists improve the processes involved, process analytical technology (PAT) tools can be used to design, analyse, and control them. This article considers the…


Improving solubility with promiscuous multi-component drug crystals

22 October 2015 | By Masataka Ito, Kiyohiko Sugano and Katsuhide Terada Faculty of Pharmaceutical Sciences, Toho University

The physicochemical properties of active pharmaceutical ingredients (APIs) are critical to the success of drug development. Most of the APIs in oral solid dosage forms are contained as drug crystals.