Whitepaper: Raman Spectroscopy for Polymer Analysis
Find out how recent advances in technology have made Raman spectroscopy better and more affordable for polymer analysis than traditional IR spectroscopy...
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Whitepapers & App Notes
Poster note: Fully automated structure verification of organic compounds by combining high resolution accurate MS with NMR data analysis
Here we describe a new approach which automates structure verification for (synthetic) chemists...
Whitepaper: Bioanalytical support in the development of biologics
In this publication Imperacer® case studies demonstrate the advantage of broad assay range combined with excellent sensitivity for several Biologics on their way from R&D to clinics...
Whitepaper: Simultaneous in situ real-time monitoring of a bioprocess
In mammalian-cell-based bioprocesses the most common critical process parameters (CPPs) include physical parameters (temperature, pressure, dissolved oxygen [DO] levels) as well as chemical properties (pH, concentrations of both substrates and byproducts) and biochemical properties (cell number and viability, cell physiology).
Whitepaper: Monitoring a pharmaceutical crystal transformation in situ
Many organic compounds can crystallize in several different forms called polymorphs. Biologically active polymorphs have different solubility and stability and, hence, different bioavailability. The effectiveness of a drug compound depends critically on its particular polymorph.
Whitepaper: Is it essential to sequence the entire 16S rRNA gene for bacterial identification?
The biopharmaceutical industry, especially manufacturing facilities, needs to implement bacterial identification to avoid the occurrence of a problematic microorganism in the final product that could be harmful for the end user and detrimental to a company’s finances and reputation.
Application note: Attaining high transient titers in CHO cells
Case study involving the use of the ExpiCHO™ mammalian transient expression system...
Application Note: In-line Raman spectroscopy for content uniformity
Raman monitoring of blended granule uniformity prior to tablet press...
Application Note: Minding your caps and tails – considerations for functional mRNA synthesis
This article discusses options for selection of reagents and the extent to which they influence synthesised mRNA functionality...
Application Note: MicroNIR PAT for blend monitoring
The aim of Quality by Design (QbD) is to build quality into a product and process from the outset. The pharmaceutical and related industries utilise powder blending operations to make solid dose drugs, yet the phenomena of powder mixing is the least understood of all sciences.
Application note: Purification of nanoparticles by Hollow Fibre Diafiltration
Hollow Fibre Diafiltration is rapid alternative to traditional methods of nanoparticle purification like ultracentrifugation.
Application Note: The sterility of the ControLyo™ process: reducing freeze dried product batch time without compromise to system integrity
Controlled nucleation is the most significant new development in freeze drying in quite some time.
Whitepaper: Feasibility of a Rapid Microbiological Method for filterable raw materials
The Milliflex® Quantum system (Merck Millipore) is a rapid method for the quantitative detection of contaminants in filterable samples...
Application Note: Are you seeing the whole picture with Raman?
Raman spectroscopy offers a rapid, convenient method for positive identification of pharmaceutical products and their raw materials – on the manufacturing floor, in inventory, and at the shipping dock.
Application note: Clean room dehumidification ensures reliable test results
Scandinavian Micro Biodevices (SMB), in Denmark, develops, produces and markets ‘point-of-care’ diagnostic systems for the veterinary market. In order to maintain a very low level of humidity in the clean room, a desiccant dehumidifier is required.
