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Microfluidics - Articles and news items

Single cell technology company Dolomite Bio celebrates a successful first year

Single cell technology company Dolomite Bio celebrates a successful first year

Supplier news / 28 March 2017 / Dolomite Bio

Dolomite Bio, a brand of Blacktrace Holdings Limited, celebrated the first anniversary of its launch on March 1st, marking the end of a fruitful year in business…

Flex-FPM used to assess water contamination risk from oocyst stiffness

Flex-FPM used to assess water contamination risk from oocyst stiffness

Supplier news / 8 November 2016 / Nanosurf

Oocysts from the waterborne protozoa Cryptosporidium are micrometer-sized organisms that can be highly infectious…

Dolomite Bio offers flexible single cell encapsulation for autoimmune disease research

Supplier news / 28 October 2016 / Dolomite Bio

Dolomite Bio’s Single Cell RNA-Seq System is helping researchers at the University of Helsinki to investigate autoimmune diseases. Focusing on gastrointestinal conditions – such as coeliac disease and inflammatory bowel disease – the Molecular Genetics of Immunological Diseases group is using the system to study T-cell activation and response at the single cell level…

Dolomite and Lab on a Chip Video Competition winner cooks up a treat

Supplier news / 26 October 2016 / Dolomite

This year’s MicroTAS Video Competition has been won by Enrica Rollo from EPFL (École polytechnique fédérale de Lausanne) in Switzerland, for her entertaining comparison between cleanrooms and kitchens…

Microfluidics in cell-to-cell signalling measurements

Microfluidics in cell-to-cell signalling measurements

Drug Targets, Issue 3 2016 / 30 June 2016 / Laura D. Casto and Christopher A. Baker, University of Tennessee

Hormones are secreted molecules that carry biological information between cells. This type of cell-to-cell communication is vital to human life, and its dysregulation often underlies disease. In fact, the largest known class of cell surface receptors involved in hormone communication, G-protein coupled receptors, are also the largest class of known drug targets. Understanding these communication processes and their dysregulation requires an ability to ‘listen in’ on hormone communications with high fidelity. To do this, highly sensitive and specific measurements of often challenging-to-detect chemical species – for example, peptides and proteins – must be made from within complex matrices such as biological fluids and tissues. This challenge has given rise to sophisticated analytical techniques for in vivo hormone measurements, including implanted microelectrodes for in situ detection of electrochemically active hormones from model organisms, and microdialysis for in situ sampling of electrically inactive molecules for ex vivo measurements…


High throughput single cell applications set to benefit from Dolomite’s novel µEncapsulator 1 System

Supplier news / 16 December 2015 / Dolomite

Dolomite, a world leader in microfluidics innovation, has launched the groundbreaking µEncapsulator 1 System, the only microfluidic product specifically designed to meet the needs of research biologists…

Dolomite celebrates 10 years of microfluidic innovation

Dolomite celebrates 10 years of microfluidic innovation

Supplier news / 1 December 2015 / Dolomite

Dolomite, part of the Blacktrace group of companies, is celebrating a decade of excellence in the design and manufacture of novel, high quality microfluidic products, including individual components such as pumps, chips, connectors, temperature controllers and sensors, software solutions and complete microfluidic systems…

Lab-on-a-chip cell culture for metabolomics

Microfluidic chips: Lab-on-a-chip cell culture for metabolomics

Issue 3 2015 / 3 July 2015 / Laura A. Filla and James L. Edwards, Saint Louis University

Microfluidic devices (MFDs) have recently become popular as cell culture platforms for metabolomics due to reduced reagent requirements and the feasibility of flow-based studies. Such devices have the potential to transform pharmaceutical research by providing an online approach to high-throughput screening which can be coupled with a variety of analysis strategies. This brief review will focus on advantages and challenges of cell culture in microfluidic chips for use in targeted and untargeted metabolomics experiments. Additionally, advances in on-chip sample preparation methods, including solid phase extraction and lysing, will be explored…